Diagnostic Importance of the Circulating C-reactive Protein in Blood and Saliva in Acute Appendicitis in Pediatric Patients
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 100
- 主要终点
- Level of CRP in blood
研究概览
简要总结
Diagnosing acute appendicitis in children is still a challenge even for experienced clinicians. Failure to recognize this acute condition can result in perforation, with consequent peritonitis, or misdiagnosis can result in negative appendectomies. C-reactive protein in blood can be elavated in children with acute appendicitis. The aim of this research is to compare the diagnostic value of C-reactive protein from the blood and saliva of children with acute appendicitis and to prove wheter the analysis of biomarker from saliva as a minimally invasive procedure can be sufficient for diagnosis.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 5 Years 至 17 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •children with age from 5 to 17 with acute abdominal pain
- •children with clinical signs of appendicitis
排除标准
- •previous diagnosis of chronic and/or malignant disease
- •children wich had previous abdominal surgery
- •pregnancy
结局指标
主要结局
Level of CRP in blood
时间窗: 72 hours
Levels of CRP in blood as measured by ELISA test
次要结局
- Level of CRP in saliva(72 hours)
研究者
Klaudio Pjer Milunovic
principal investigator
University Hospital of Split