A randomized controlled study on the treatment of severe acute pancreatitis with intraperitoneal hypertension through nasogastric nutrition tube administration of Gansui
- Conditions
- severe acute pancreatitis
- Registration Number
- ITMCTR2024000034
- Lead Sponsor
- Guangdong Provincial Hospital of Chinese Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- Not specified
(1) Meets the diagnostic criteria for moderate severe acute pancreatitis or severe acute pancreatitis (refer to the 2021 edition of Chinese Guidelines for Diagnosis and Treatment of Acute Pancreatitis);
(2) Gansui can be administered through a nasojejacual nutrition tube;
(3) Voluntarily participate in this study and sign an informed consent form;
(4) Age = 18 and = 75 years old, regardless of gender.
(1) No gastrointestinal administration route;
(2) Have a history of major digestive surgery in the past;
(3) Patients who are currently participating in or have participated in other clinical trials within the month prior to this study;
(4) Allergic reactions to therapeutic drugs;
(5) Patients with fertility requirements or those who are pregnant or breastfeeding;
(6) Liver function: Child Pugh C-grade;
(7) Kidney function: CKD stage 4 or 5.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method intra-abdominal pressure;
- Secondary Outcome Measures
Name Time Method Abdominal perfusion pressure;Hospitalization expenses;lipase;CT severity index score;arterial oxygenation index, CO2 partial pressure;ICU hospitalization days;amylase;Incidence of complications;Hospitalization days;C-reactive protein;Procalcitonin;abdominal circumference;APACHE II score;White blood cell count, percentage of neutrophils;Ventilator parameters (mean airway pressure, airway resistance);Gastrointestinal motility score;