Comparison of blood vessel changes in healthy and low vision eyes with the help of Optical coherence tomography angiography

Not yet recruiting

Brief Summary: Anisometropicamblyopia is the second leading cause ofamblyopia in children with strabismic amblyopia being first. Several studieshave been reported stating anatomical and functional changes in the visualcortex and LGB(lateral geniculate body) nucleus in patients with amblyopia. Butinvolvement of retina in development of amblyopia is still a matter of debate,

Though there are many studies recentlyabout the optic nerve head morphology, choroidal thickness ,there is very less study onthe retinal vasculature in amblyopic patients.Evaluation of the vascular system of the retina is alsoof interest in terms of potential clinical and prognostic value of vascularparameters in patients with macular diseases.

With the advent of OCTA (Optic Coherence Tomography Angiography) , a new and non invasive imaging modality,it permits visualisation of the microvasculature of the retinathroughout its depth , allowing for the identification of superficial and deep retinal capillaryplexus.

Although macular findings by OCTA inpatients with ambylopia have been extensively studied, mostof these focussed on fovealthickness and retinal layer abnormalities.

This study is designed to investigatepotential changes in retinal microcirculation in children with anisometropic amblyopia when compared to healthyeyes.

Recruitment & Eligibility

Inclusion Criteria

Children aged 5 to 15 years newly diagnosed with anisometropic amblyopia.

Exclusion Criteria

Children less than 5 years and more than15 years Children who are previously on treatment for anisometropic amblyopia.
Presence of strabismus, deprivation amblyopia, nystagmus History of previous ocular surgery, intraocular inflammation, corneal disease, retinal disease or optic nerve disease Ocular media opacities including cataract Other diseases of the visual pathway Glaucoma, neurological disease Insufficient cooperation.

Primary Outcome Measures

Name	Time	Method
Relationship between retinal microvasculature and anisometropic amblyopia	Baseline

Secondary Outcome Measures

Name	Time	Method
Any changes in retinal microcirculation compared to amblyopic eye and normal eye at the end of 1 year of study	1 year

Locations (1): Sankara Eye Hospital
🇮🇳
Coimbatore, TAMIL NADU, India
Sankara Eye Hospital
🇮🇳Coimbatore, TAMIL NADU, India
Tisha Thomas Menacherry
Principal investigator
8281829912
daphtish1996@gmail.com