AI-Powered Research

For this study we will include 68 healthy sexually functional women between 18-45 years. Participants will be included if they have
had no sexual complaints for at least one year, and are sexually active.
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range 68
F.1.3 Elderly (>=65 years) no
F.1.3.1 Number of subjects for this age range

Exclusion Criteria

- Age < 18 or > 45 years
- Homosexual orientation
- Pregnancy or lactation
- Colour blindness
- A diagnosis of affective, psychotic or substance related disorder
according to DSM 5.
- Current or recurrent use (less than 4 weeks before participation) of
medication that may affect sexual response. To determine possible
sexual side-effects the 'Farmacotherapeutisch kompas' 2015 will be
used.
- Current or previous disorders of the genitals or treatments for such
disorders that may influence the sexual response or the measurement of
the response.
- Other medical disorders that may influence the sexual response or the
measurement of the response.
- Current or recurrent use (less than 4 weeks before participation) of
medication that may affect or interact with the effects of DCS. To determine possible contra-indications, instructions for use as supplied
by 'King Pharmaceuticals' will be used.
- Current or previous disorders (like severe anxiety or psychosis, liver
disease or severe renal insufficiency, epilepsy) that increase the
possibility of side effects of DCS and for which usage of DCS is contraindicated.
- Alcohol or drug use on the night and day before participation, as well
as alcohol and drug use between test moments (day 1 and day 2).

Study & Design

Study Type: Interventional clinical trial of medicinal product

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Main Objective: The aim of the study is: to investigate the effect of DCS on the physiological and subjective correlates reflecting conditioned sexual response, and sexual memory formation. <br><br>Hypothesis: We hypothesize that administration of DCS after a classical conditioning procedure will enhance sexual memory formation of conditioned sexual responses. Compared to the placebo-condition, for the DCS condition an increase in sexual conditioned responses elicited by reward-conditioned cues will be seen on a test phase 24hrs later. The DCS condition will show stronger conditioned genital and subjective responding, also outside the original acquisition context, compared to the placebo condition.<br>;Secondary Objective: n.a.;Primary end point(s): 1) measures of vaginal pulse amplitude (VPA) assessed by a vaginal<br>photoplethysmograph; 2) Subjective ratings of US expectancy, affective<br>valence and sexual arousal; 3) implicit attitude;Timepoint(s) of evaluation of this end point: March 31th 2016

Secondary Outcome Measures