Cholinergic Status and the Metabolic Syndrome
试验速览
- 阶段
- 不适用
- 入组人数
- 50
- 主要终点
- total soluble circulation capacity for acetylcholine hydrolysis
研究概览
简要总结
The investigators aims in the current study are to examine whether the cholinergic status should be considered as another risk factor for the metabolic syndrome and it's co-morbidities and to test the effect of a hypocaloric high complex carbohydrates diet on the cholinergic status of overweight and obese adults with and without the metabolic syndrome.
详细描述
Intervention studies have demonstrated that the autonomic disturbances of the metabolic syndrome may be reversible. A reduction in body weight induced by a hypocaloric diet exerts a marked reduction in sympathetic activity in obese people with or without metabolic syndrome. Incorporation of regular, moderate intensity aerobic exercise training during a dietary weight loss program does not confer additional benefits on resting sympathetic neural activity, compared with weight loss by diet alone. A new method has been developed to examine the sympathetic-parasympathetic status of an individual - the cholinergic status. Cholinergic Status represents the total soluble circulation capacity for acetylcholine hydrolysis. Higher cholinergic status means the individual is more sympathetic .
A cross sectional study that took place in Tel Aviv Sorasky medical center and included 632 participants found that the cholinergic status is related to metabolic syndrome parameters in a dose response manner and that it correlates significantly with glucose,HbA1c, lipid profile and hs-CRP.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 35 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •BMI ≥ 25kg/m2
- •Stable weight (±1kg)in the previous six months
- •Non smokers
排除标准
- •Type II diabetes
- •Hypertension pharmacologically treated
- •Cardiovascular disease
- •Renal disease
- •Cirrhosis and end-stage liver failure
- •Thyroid disease
- •Cerebrovascular disease
- •Autoimmune disease
- •Chronic inflammatory disease
- •Surgery or heart catheterization in the previous six months
- •Use of drugs known to affect measured parameters
结局指标
主要结局
total soluble circulation capacity for acetylcholine hydrolysis
时间窗: 8 weeks or more
次要结局
- Inflammatory markers(8 weeks or more)
- ROTEM - rotation thromboelastometry(8 weeks or more)
- Metabolic markers(8 weeks or more)