The impact of uterine re-curettage on the number of chemotherapy courses in treatment of post molar gestational trophoblastic neoplasia. A randomized – controlled study.
Completed
- Conditions
- Persistent trophoblastic disease, molar pregnancy, chemotherapy, curettage.Persisterende trofoblast, mola zwangerschap, chemotherapie, curettage
- Registration Number
- NL-OMON23724
- Lead Sponsor
- HC van Doorn ErasmusMC, Daniel den HoedclinicRotterdam+31107041263h.vandoorn@erasmusmc.nlNo sponsor
- Brief Summary
Reda A Hemida, EmanToson, H.C. Van Doorn.The impact of uterine re-curettage, pre-evacuation and week-one level of hCG on the number of chemotherapy courses in treatment of post molar GTN. Journal of Excremental Ther and Oncol., Vol 9. P 217-230.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 80
Inclusion Criteria
1. Non metastatic post molar GTD cases who will be diagnosed after:
A. Persistent positive hCG more than 6 months after evacuation of molar pregnancy;
Exclusion Criteria
1. Post molar GTD with distant metastasis;
2. History of uterine perforation;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The number of chemotherapy courses needed to reach complete response.
- Secondary Outcome Measures
Name Time Method 1. Response rate;<br /><br>2. Rate of relapse of GTD in both groups;<br /><br>3. Duration of treatment;<br /><br>4. The need for hysterectomy;<br /><br>5. Complications of uterine re-curettage in group A;<br /><br>6. Number of cycles in relation to histopathological findings.