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Development of a Therapeutic Endpoint in Pediatric Rheumatologic Conditions

Recruiting
Conditions
Systemic Lupus Erythematosus
Juvenile Idiopathic Arthritis
Fibromyalgia
Registration Number
NCT04833465
Lead Sponsor
Children's National Research Institute
Brief Summary

The overarching goal of this study is the development of a physiologic endpoint of pain and treatment effect in three distinct rheumatology populations. This would enable objective assessment of pain and treatment in these populations and enable a much more precise approach to treatment. Such an endpoint stands to significantly improve outcomes in these patients by eliminating the need for a trial-and-error approach to treatment. This is a single site observational study that aims to collect initial pilot data in three distinct patient groups. As this is observational, there is no randomization or blinding in the study. Patients will be followed for a period of one year after enrollment. Baseline measurements will be taken at the time of enrollment, and at each subsequent standard of care clinic visit as feasible, for a period of one year. As this is an observational study, there will be no change to the treatment for any patient due to research activities. The primary objective of this study is the characterization of the nociceptive index in three pediatric rheumatology populations. The secondary objective is the characterization of the nociceptive index in these populations in response to standard of care interventions. This is necessary to demonstrate the ability of this approach to serve as an endpoint of treatment effect.

Detailed Description

Not available

Recruitment & Eligibility

Status
RECRUITING
Sex
All
Target Recruitment
90
Inclusion Criteria

In order to be eligible for inclusion in the study, an individual must meet all of the following criteria:

  • Male or female ≥ 5 years of age at screening.
  • Documentation of a JIA, SLE or FM diagnosis as evidenced by history
Exclusion Criteria

Any individual who meets any of the following criteria will be excluded from participation in this study:

• Documented history of eye disease precluding pupillometry

Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Index Characterization1 Year

The primary objective of this study is the characterization of the nociceptive index in three pediatric rheumatology populations.

Secondary Outcome Measures
NameTimeMethod
Treatment Effect1 Year

The secondary objective is the characterization of the nociceptive index in these populations in response to standard of care interventions. This is necessary to demonstrate the ability of this approach to serve as an endpoint of treatment effect.

Trial Locations

Locations (1)

Children's National Health System

🇺🇸

Washington, District of Columbia, United States

Children's National Health System
🇺🇸Washington, District of Columbia, United States

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