High Flow Nasal Cannula on Exercise Endurance in COPD
- Conditions
- COPD
- Interventions
- Device: high flow nasal cannulaDevice: nasal cannula
- Registration Number
- NCT03883256
- Lead Sponsor
- Chang Gung University
- Brief Summary
Ventilation limitation has a significant adverse effects on cardiovascular function and cerebral oxygenation during exercise in patients with COPD. High flow nasal cannula (HFNC) has been shown to improve ventilation by washing out the anatomical dead space and permitting a better gas exchanges. Moreover, it is able to ensure the desired inspired oxygen fraction (FiO2) even at high level of patient's minute ventilation by minimizing the room air entrainment. The effects of HFNC on exercise performance in terms of hemodynamic changes and exercise endurance in COPD patients remain unclear. The primary purpose of this study is to examine the effects of HFNC on the exercise endurance in COPD patients. The investigator's secondary purpose is to investigate whether HFNC could improve efficiency of ventilation, leading to an improvement of hemodynamic and cerebral oxygenation response.
- Detailed Description
This is a randomized crossover study. Patients who have been diagnosed as COPD will be recruited from outpatient department. After signing informed consent form, patients undertake an incremental exercise test and two constant load exercise at the 70% of maximum workload achieved at a previous incremental exercise test on arm ergometer in two separate days. The constant load tests will be performed with HFNC and with nasal cannula at the same inhaled oxygen fraction in random order. The hemodynamics CO, SV, EF of all subjects during exercises will be measured by a bioelectrical impedance device (Physioflow), and cerebral oxygenation status (oxygenated hemoglobin (O2Hb), deoxygenated hemoglobin (HHb), total hemoglobin (tHb) was measured by a near infrared spectrophotometer (NIRS).
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 15
- with diagnosis of COPD
- OPD patients
- has no AE (within 1 month)
- not receiving any O2 therapy at home
- no smoking or quick
- fever
- unstable hemodynamics at resting
- orthopadeic or neurologic problems that limited exercise
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description high flow nasal cannula high flow nasal cannula Subjects perform a constant-load exercise test with high flow nasal cannula oxygen device. nasal cannula nasal cannula Subjects perform a constant-load exercise test with nasal cannula oxygen device.
- Primary Outcome Measures
Name Time Method exercise time with high flow nasal cannula end of the exercise test in the session of constant-load exercise test with high flow nasal cannula oxygen device the total duration that subjects performed constant-load exercise test with high flow nasal cannula oxygen device
exercise time with nasal cannula end of the exercise test in the session of constant-load exercise test with nasal cannula oxygen device the total duration that subjects performed constant-load exercise test with nasal cannula oxygen device
- Secondary Outcome Measures
Name Time Method Difference in muscle tissue oxygenation Baseline and 48 hours after baseline ] Difference in end-exercise muscle tissue oxygenation in constant-load exercise test between HFNCO and NC
Difference in cardiac output Baseline and 48 hours after baseline ] Difference in end-exercise cardiac output in constant-load exercise test between HFNCO and NC
Difference in stroke volume Baseline and 48 hours after baseline ] Difference in end-exercise stroke volume in constant-load exercise test between HFNCO and NC
Difference in cerebral tissue oxygenation Baseline and 48 hours after baseline ] Difference in end-exercise cerebral tissue oxygenation in constant-load exercise test between HFNCO and NC
Trial Locations
- Locations (1)
Chang Gung University
🇨🇳TaoYuan City, Taiwan