Cardiac Strain Using Speckle Tracking Echocardiography During Orthotopic Liver Transplantation

Terminated

• Conditions: Reperfusion Injury; Liver Transplant Disorder

• Registration Number: NCT04316468
• Lead Sponsor: Mayo Clinic

Brief Summary

Researchers are trying to improve the understanding of systolic function of the heart at the time of liver reperfusion in patients undergoing orthotopic liver transplantation.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-03-10
• Study First Submitted: 2020-03-19
• Study First Submitted QC: 2020-03-19
• Study First Posted: 2020-03-20
• Status Verified: 2024-04
• Primary Completion: 2024-04-08
• Study Completion: 2024-04-08
• Last Update Submitted: 2024-04-08
• Last Update Posted: 2024-04-10

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Age greater than 18 years
• Undergoing primary orthotopic liver transplantation

Exclusion Criteria

• Redo orthotopic transplantation
• Acute or fulminant liver failure
• Patient with pre-existing atrial fibrillation or hypertrophic cardiomyopathy
• Patients with an abnormal preoperative stress test (EF <55%, areas of prior infarct, ongoing ischemia)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Degree of change in cardiac strain	Up to 1 hour after graft reperfusion	Evaluate the degree of change to cardiac strain using speckle tracking echocardiography

Secondary Outcome Measures

Name	Time	Method
Pattern of right and left ventricular strain	Up to 5 hours from the time of surgery start	Describe the pattern of right and left ventricular strain throughout the course of orthotopic liver transplantion.

Trial Locations

Locations (1)

Mayo Clinic in Florida; 🇺🇸 Jacksonville, Florida, United States