Neuronal Markers of Grapheme-phoneme Training Response for Prediction of Successful Reading Acquisition in Children at Familial Risk for Developmental Dyslexia
试验速览
- 阶段
- 不适用
- 入组人数
- 110
- 试验地点
- 1
- 主要终点
- Changes in reading and spelling performance
研究概览
简要总结
The long-term goal of this study is to improve prediction of poor reading outcome at preschool age by using a combination of behavioural and neuroimaging measures and to evaluate a specific computerized training program to support children with problems during reading acquisition.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 5 Years 至 9 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •for all groups:
- •Healthy, native (CH-) German speaking subjects, with an estimated non-verbal intelligence quotient (IQ) >=80, without neurological and/or psychiatric disorder (except for attention deficit hyperactivity disorder, specific learning disorders, developmental language impairments)
- •Additional criteria for subgroups:
- •Recruitment of preschoolers (aged 5.5-7.5 years):
- •Healthy children with increased risk for developmental dyslexia in their second year at kindergarten
- •Recruitment of children in first grade (aged 6.5-8.5years):
- •Children showing impairments in learning to read (first/second grade).
- •Adults (aged 20-40 years):
- •Healthy, normal reading
排除标准
- •for all groups:
- •MRI contraindications
- •No history of premature delivery and/or maternal reports of severe prenatal, perinatal or postnatal complications.
研究组 & 干预措施
Computerized reading training first
Cross-over design: group first receives the intervention
干预措施: Computerized reading training (Other)
Waiting Control First
Cross-over design: group first serves as waiting control
干预措施: Computerized reading training (Other)
结局指标
主要结局
Changes in reading and spelling performance
时间窗: Participants will be tested at three times for the duration of the cross-sectional intervention, an expected average of 8 months
Performance in normed reading and/or spelling (standardized tests) as a result of reading acquisition and training
次要结局
- Developmental and training induced changes in functional brain activation and brain structure(Participants will be tested after an expected average of 8, 12 and 16 months)
- Accuracy of prediction on reading performance outcome(Participants will be tested at T1 and on average 8 months later)