Correlation Between Serum Copper and Cardiac Enzymes in Acute Myocardial Infarction
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- Serum copper level
研究概览
简要总结
This study aims to investigate the correlation between serum copper levels and cardiac enzymes in patients with acute myocardial infarction (AMI).
详细描述
Acute myocardial infarction (AMI) is one of the most serious types of coronary artery disease (CAD). In CAD, coronary blood flow is drastically reduced or interrupted, causing severe myocardial ischemia or necrosis.
Cardiac troponin I (TNI), creatine kinase (CK), and creatine kinase MB (CK-MB) are the most commonly used biomarkers for AMI clinical diagnosis. Among them, cardiac troponin is a highly specific biomarker for the diagnosis of AMI. However, the sensitivity is not good in the first few AMI hours, and false-positive values may occur in severe heart failure, arrhythmia, and myocarditis.
Copper is vital in multiple enzymes necessary for antioxidant protection, such as Superoxide dismutases (SOD) and ceruloplasmin. SOD is an enzyme that changes superoxide radicals into hydrogen peroxide, whereas ceruloplasmin is an antioxidant protein that aids in eliminating free radicals.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥18 years old.
- •Both sexes.
- •Patients with acute myocardial infarction (AMI). AMI are defined as patients complaining of typical continuous chest pain for more than 30 min: ST-segment elevation of more than 0.1 mV in two or more successive leads or ST-segment depression of more than 0.1 mV in two or more successive leads monitored by a standard 12-lead ECG and rise of either creatine kinase (CK) or MB fraction of creatine kinase (CKMB) to greater than twice the normal level or elevation of troponin I [cardiac troponin T (cTnT)] more than or equal to 0.1 ng/ml
排除标准
- •Patients with insufficient clinical information.
- •Passed time MI (if patients presented with symptoms that lasted >24 h).
- •Cardiogenic shock.
- •Chronic kidney disease.
- •Chronic liver cell failure.
- •Significant valvular heart disease.
- •Hematological disease.
- •Malignancy.
- •Severe liver or renal disease.
- •Systemic inflammatory disease.
- •Active infection.
- •Autoimmune disease.
- •Patients on steroids whatever the cause is.
结局指标
主要结局
Serum copper level
时间窗: Immediately after echocardiography (Up to 1 hour)
Serum copper level will be recorded.
次要结局
- Correlation between copper zinc and cardiac enzyme(Immediately after echocardiography (Up to 1 hour))
- Creatine kinase(Immediately after echocardiography (Up to 1 hour))
- MB fraction of creatine kinase(Immediately after echocardiography (Up to 1 hour))
- Cardiac troponin T(Immediately after echocardiography (Up to 1 hour))
研究者
Remon Saleh Adly
Lecturer of Cardiovascular, Faculty of Medicine, Sohag University, Sohag, Egypt.
Sohag University