Comparison of Magnetic Resonance (MR) Imaging Against Clinical Criteria in the Diagnosis and Monitoring of Adult Idiopathic Myopathy
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Myositis
- Sponsor
- University of Warwick
- Enrollment
- 70
- Locations
- 3
- Primary Endpoint
- MR signal (T1w, T2w and STIR sequences) in muscle.
- Last Updated
- 13 years ago
Overview
Brief Summary
A prospective observational study to determine the effectiveness of magnetic resonance (MR) imaging in the diagnosis and monitoring of idiopathic myopathy in adult humans.
Detailed Description
Idiopathic inflammatory myopathies are a heterogeneous group of conditions characterised by skeletal muscle inflammation leading to proximal muscle weakness, often with tenderness, and occasionally dermatological manifestations. Diagnosis is clinical and is based on the Bohan and Peter criteria which comprises clinical examination, serological markers, electromyography (EMG) and muscle biopsy. This has relatively poor sensitivity and specificity. Muscle biopsy in particular has a false negative rate of 10-15% and is invasive. Clinical criteria also lack the discriminatory power to differentiate between recurrent (or breakthrough) myopathy and myopathy secondary to treatment with corticosteroid. Magnetic resonance (MR) imaging has the advantage of being non-invasive, and is able to discriminate between different tissues, and to identify areas of inflammation. The aim of this study is to assess the effectiveness of MR sequences in the diagnosis of myopathy, monitoring of treatment response, and in differentiating between breakthrough myopathy and steroid-induced myopathy.
Investigators
Dr. Terence Jones
Clinical Research Fellow in Radiology
University of Warwick
Eligibility Criteria
Inclusion Criteria
- •Any adult patient referred for an MR scan with a suspected clinical diagnosis of myopathy.
Exclusion Criteria
- •Patient unable or unwilling to have an MR scan.
- •Standard MR exclusion criteria will apply.
Outcomes
Primary Outcomes
MR signal (T1w, T2w and STIR sequences) in muscle.
Time Frame: 2 years
The correlation between MR signal and the clinical criteria will be measured
Secondary Outcomes
- Correlation between MR appearances (T1w, T2w and STIR signal on MR)and the symptom severity (Bohan and Peter criteria)(2 years)
- Difference in MR signal between myopathy and steroid-induced myopathy, with sensitivity and specificity(2 years)