Pathophysiology of diaphragm fatigue in patients with Amyotrophic lateral sclerosis
Recruiting
- Conditions
- G12.2Motor neuron disease
- Registration Number
- DRKS00016013
- Lead Sponsor
- Institut für Schlafmedizin und neuromuskuläre Erkrankungen, Universitätsklinikum Münster
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 10
Inclusion Criteria
a. Age > 18 years (no age limit)
b. able to consent
c. likely or definite diagnosis of Amyotrophic lateral sclerosis accoring to the revised El-Escrial criteria
Exclusion Criteria
- other severe internistic pre-existing conditions, especially insulin-dependent diabetes or severe endstage renal impairment
- severe neurological pre-existing conditions, especially brainstem infarction
- intake of opioids
- severe psychiatric pre-existing conditions
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Twitch transdiaphragmatic pressure after magnetic cervical stimulation of the phrenic nerves [cmH2O]
- Secondary Outcome Measures
Name Time Method