Dietary Salt Intake and Vascular Function
Early Phase 1
Completed
- Conditions
- Healthy
- Registration Number
- NCT00590512
- Lead Sponsor
- Brigham and Women's Hospital
- Brief Summary
The purpose of this study is to look at the effects of high- and low-salt diets on blood vessel function in healthy subjects.
- Detailed Description
Healthy volunteers will be enrolled in a dietary sodium intervention to examine impact on vascular function.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 133
Inclusion Criteria
- Healthy male, African-American volunteers
- 18-35 years of age,
- No personal or first degree relative with hypertension or diabetes,
- Blood pressure <130/85 mmHg and > 90/60 at the screening visit,
- Body mass index <30 kg/m2,
- No clinically significant abnormalities on screening tests (complete blood count, serum electrolytes, liver enzymes, thyroid stimulating hormone, urinalysis and electrocardiogram).
Exclusion Criteria
- Alcohol intake >2 beverage/night,
- Smoking,
- Recreational drug use,
- Personal history of coronary disease, diabetes, hypertension, stroke, kidney disease, or illness requiring overnight hospitalization in the past 6 months,
- Prescription or herbal medication use,
- Ischemic changes on resting electrocardiogram,
- Known hypersensitivity to any of the study drugs,
- Other active medical problems detected by examination or laboratory testing.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method endothelial function one week
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms link high sodium intake to vascular dysfunction in healthy individuals?
How does dietary sodium intervention compare to standard antihypertensive therapies in vascular function improvement?
Are there specific biomarkers that correlate with vascular response to low sodium diets in normotensive subjects?
What adverse events are associated with low sodium dietary interventions and how are they managed clinically?
How do high and low sodium diets interact with other cardiovascular risk factors in healthy populations?
Trial Locations
- Locations (1)
Brigham and Women's Hospital
🇺🇸Boston, Massachusetts, United States
Brigham and Women's Hospital🇺🇸Boston, Massachusetts, United States