The role of serum cardiac biomarkers and left ventricular strain imaging for detecting early radiation induced myocardial damage

Not Applicable

Completed

• Conditions: eft ventricular dysfunction; Breast Cancer; Radiation Therapy; Left ventricular dysfunction; Cardiovascular - Other cardiovascular diseases; Cancer - Breast

• Registration Number: ACTRN12618002015224
• Lead Sponsor: Austin Health Medical Research Foundation

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-12-17
• Study Completion: 2020-02-03
• Last Update Posted: 28 June 2021

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 20

Inclusion Criteria

All women over the age of 18 years with left sided breast cancer undergoing radiation therapy at the Olivia Newton John Cancer and Wellness Centre

Exclusion Criteria

Patients who are receiving adjuvant chemotherapy or Herceptin. Patients who are unable to provide informed consent will be excluded. Additionally, patients who withdraw their consent at any stage will be excluded from the rest of the study.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To measure the change in serum high-sensitivity troponin and NT-pro BNP levels in patients during radiation therapy [Serum testing at enrolment and at the end of radiation therapy (6 weeks)]

Secondary Outcome Measures

Name	Time	Method
To measure the change in left ventricular strain rate in patients undergoing radiation therapy using global longitudinal strain and strain rate on transthoracic echocardiography.[6 weeks post-enrolment (end of radiation therapy)]