Metabolic Syndrome, Inflammation, and Risk of Cognitive Decline
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 2,632
研究概览
简要总结
The purpose of this study is to determine if the metabolic syndrome is a risk factor for cognitive decline and if this association is modified by inflammation.
详细描述
The metabolic syndrome is a clustering of several commonly occurring disorders that include abdominal obesity, high triglycerides, low HDL cholesterol, high blood pressure, and insulin resistance. This study was conducted to determine if, as hypothesized, the presence of the metabolic syndrome is associated with more cognitive decline and greater risk of developing cognitive impairment, and whether this risk is affected by the level of inflammatory markers in the blood.
This 5-year prospective observational study was conducted from 1997 to 2002 at community clinics in two locations. A total of 2632 black and white participants, aged 70 to 79 years, were recruited from the 3075 participants in the Health, Aging and Body Composition (ABC) study conducted during the same period. Participants were screened for presence of metabolic syndrome, cognitive status, inflammatory markers, and a clinic examination was administered, when the study began and at the year 3 and 5 follow-up visits.
研究设计
- 研究类型
- Observational
- 观察模型
- Natural History
- 时间视角
- Prospective
入排标准
- 年龄范围
- 70 Years 至 79 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Aged 70 to 79
- •White or Black
- •Community-dwelling in Memphis, TN or Pittsburgh, PA vicinity
- •Well-functioning (no difficulty in walking a quarter of a mile or going up 10 steps without resting)
排除标准
- •Any difficulty with activities of daily living
- •Clinical dementia
- •Inability to communicate with interviewer
- •Intention of moving out of vicinity in the next year
- •Active treatment for cancer in the previous 3 years
- •Participation in a trial involving a lifestyle intervention