Cardiopulmonary Exercise Testing as an Outcome Predictor in Coronary Artery Bypass Surgery

Not Applicable

Completed

• Conditions: Coronary Artery Disease; Surgery--Complications
• Interventions: Diagnostic Test: Cardiopulmonary Exercise Testing

• Registration Number: NCT03376542
• Lead Sponsor: Eduardo Tibirica, MD, PhD

Brief Summary

This is a prospective cohort study of patients undergoing coronary artery bypass graft surgery. Prior to surgery, participants will undergo submaximal cardiopulmonary exercise testing on a treadmill. Participants will be followed for one month after surgery to assess mortality and non fatal complications.

Detailed Description

Coronary artery bypass surgery (CABG) is a complex and expensive procedure with great potential for morbidity and mortality. Preoperative evaluation is of paramount importance to optimize results. There is much evidence about the benefits of the cardiopulmonary exercise testing (CPET) in the evaluation of preoperative risk in non-cardiac surgeries. Thus, it is important to evaluate the relationship between parameters obtained in the CPET and the outcomes after cardiac surgery, especially CABG.

This is a prospective cohort study in which participants undergo submaximal CEPT on a treadmill prior to CABG. Participants will be followed up for one month after surgery to assess mortality and non fatal complications. It is expected that poor cardiopulmonary fitness is related to worse outcomes in CABG, as already observed in other cardiac pathologies and in non-cardiac surgery.

Study Timeline

• Study Start: 2017-08-01
• Study First Submitted: 2017-11-22
• Study First Submitted QC: 2017-12-15
• Study First Posted: 2017-12-18
• Primary Completion: 2019-01-10
• Study Completion: 2019-01-10
• Status Verified: 2019-03
• Last Update Submitted: 2019-03-11
• Last Update Posted: 2019-03-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Patients undergoing coronary artery bypass grafting surgery at the National Institute of Cardiology, Ministry of Health, Rio de Jnaeiro, Brazil.

Exclusion Criteria

• Angina CCS IV, heart failure NYHA IV, inability to walk on a treadmill, severe left main coronary artery lesion.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Cardiopulmonary exercise testing	Cardiopulmonary Exercise Testing	All patients included in the study will perform cardiopulmonary exercise testing prior to surgery

Primary Outcome Measures

Name	Time	Method
Mortality after cardiac surgery	30 days	number of deaths during the first 30 days after cardiac surgery

Trial Locations

Locations (1)

National Institute of Cardiology; 🇧🇷 Rio de Janeiro, Brazil