Best Cardiac Output During Cardiopulmonary Bypass
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Bypass Complications
- Sponsor
- Aalborg University Hospital
- Enrollment
- 20
- Locations
- 1
- Status
- Completed
- Last Updated
- 14 years ago
Overview
Brief Summary
The purpose of this study is to determine whether the patients cardiac output measured before cardiopulmonary bypass (CPB), is more sufficient to secure the patients oxygen needs than the estimated cardiac output from Ficks principle, and thereby prevent organ failure.
Detailed Description
For more than 50 years, CPB has been used to mechanically support the functions of the heart and lungs. In early studies, systemic oxygen uptake, calculated using Ficks global principle, was used to assess the efficiency of CPB. Using this measure of efficiency, a pump flow rate in liters per minute, based on the product of the body surface area (BSA) and a constant of 2.4 was found adequate to perfuse the body during normothermia. Ficks global principle is still used together with other methods to secure adequated perfusion under CPB. The purpose of this study is to determine whether the patients cardiac output measured before CPB, is more sufficient to secure the patients oxygen needs than the estimated cardiac output from Ficks principle, and thereby prevent organ failure. The hypothesis is that the patients cardiac output is a better marker for the optimal cardiac output than the estimated cardiac output.
Investigators
Eligibility Criteria
Inclusion Criteria
- •patients admitted for scheduled cardiac surgery during cardiopulmonary bypass
- •Aged 18-90 years
- •LVEF \> 50 %
- •written consent from the patients
Exclusion Criteria
- •Former cerebral emboli
- •Former head trauma
- •known stenosis of the arteria carotis
Outcomes
Primary Outcomes
Not specified