Creatine and Ubiquinol for Sperm Quality

Not Applicable

Completed

• Conditions: Sperm Count, Low; Oligospermia
• Interventions: Dietary Supplement: Supplement 2; Dietary Supplement: Supplement 1; Dietary Supplement: Placebo

• Registration Number: NCT06202469
• Lead Sponsor: University of Novi Sad, Faculty of Sport and Physical Education

Brief Summary

This randomized controlled double-blind parallel-group interventional trial explores the impact of 8-week creatine supplementation, with or without ubiquinol, on sperm quality biomarkers in normospermic and oligospermic men. It aims to determine potential enhancements in sperm health to provide insights into male fertility and reproductive health improvement strategies.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-12-15
• Study First Submitted: 2023-12-28
• Study First Submitted QC: 2024-01-09
• Study First Posted: 2024-01-11
• Primary Completion: 2024-05-31
• Study Completion: 2024-06-30
• Status Verified: 2024-12
• Last Update Submitted: 2024-12-03
• Last Update Posted: 2024-12-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 18

Inclusion Criteria

• Age 18 - 35 years
• Sperm quality test available (at least half will have low sperm quality)
• Informed consent
• Healthy BMI (18.5 - 24.9 kg/m2)

Exclusion Criteria

• Major chronic disease and acute injuries
• History of dietary supplement use during the past 28 days
• No consent to randomization
• Participation in other studies

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Supplement 2	Supplement 2	Creatine monohydrate plus ubiquinol
Supplement 1	Supplement 1	Creatine monohydrate
Placebo	Placebo	Inulin

Primary Outcome Measures

Name	Time	Method
Sperm concentration	Change from baseline sperm concentration at 8 weeks	Number of sperm per milliliter of semen

Secondary Outcome Measures

Name	Time	Method
Total antioxidant capacity	Change from baseline total antioxidant capacity at 8 weeks	Level of total antioxidant capacity in semen
Creatine kinase	Change from baseline creatine kinase at 8 weeks	Level of creatine kinase in semen
The World Health Organisation-Five Well-Being Index (WHO-5)	Change from baseline WHO-5 at 8 weeks	The World Health Organisation-Five Well-Being Index (WHO-5) is a short self-reported measure of current mental wellbeing.The raw scores are transformed to a score from 0 to 100, with lower scores indicating worse well-being.
Creatine	Change from baseline creatine at 8 weeks	Level of creatine in semen

Trial Locations

Locations (1)

FSPE Applied Bioenergetics Lab; 🇷🇸 Novi Sad, Vojvodina, Serbia