Different Endoscopic Gastric Cancer Risk Assessments for the Detection of Early Gastric Cancer
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 3,500
- 试验地点
- 1
- 主要终点
- Early gastric cancer detection rate
研究概览
简要总结
The Kimura-Takamoto classification established in Japan can observe the extent of gastric atrophy in real-time under endoscopy, and diffuse atrophy also indicates an increased risk of gastric cancer. Recent studies have found that the evaluation of intestinal metaplasia score (EGGIM score) of various stomach parts by electronic staining can well identify OLGIM III\ IV patients. Although the Kimura-Takamoto classification and EGGIM score can evaluate the risk of gastric cancer in patients, only in cross-sectional studies, it is not clear the diagnostic value of risk assessment in population screening. Early gastric cancer has the characteristics of hidden lesions and a high rate of clinical missed diagnosis. Concentrating high-risk groups through risk scores is expected to guide endoscopic doctors to conduct a targeted careful examination. However, it is not clear whether Kimura-Takamoto classification and EGGIM score can improve the detection rate of early gastric cancer in clinical practice.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Screening
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 40 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients aged 40-80 years undergoing gastroscopy
- •Patients intend to undergo ESD treatment
排除标准
- •patients with severe cardiac, cerebral, pulmonary or renal dysfunction or psychiatric disorders who cannot participate in gastroscopy
- •Patients with previous surgical procedures on the stomach
- •patients with contraindications to biopsy
- •Patients who refuse to sign the informed consent form.
结局指标
主要结局
Early gastric cancer detection rate
时间窗: 36 months
The detection rate of early gastric cancer
次要结局
未报告次要终点
研究者
Yanqing Li
Vice President of Qilu Hospital
Shandong University