Examination of Pyelonephritis In Children with magnetic resonance imaging (MRI)

Completed

Conditions: Pyelonephritis
Urological and Genital Diseases

Registration Number: ISRCTN36325312

Lead Sponsor: Foreest Medical School (Netherlands)

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 80

Inclusion Criteria

1. Patients from 0 to 18 years, with:
1.1. Acute pyelonephritis, defined as a urinary tract infection (UTI) with a body temperature above 38 °C
1.2. Suspicion of acute pyelonephritis, suggested by symptoms of a UTI and flank pain
2. For young children (under the age of 1 year and in the pre-verbal phase) other clinical symptoms can suggest pyelonephritis. This is bacteriuria with either fever, vomitus, lethargia, anorexia, abdominal pain, pollakisuria or flank pain
3. Outside the study setting, the patient would have received a dimercaptosuccinic acid (DMSA) scan
4. Patients, or a legal representative, must be able to give informed consent, and the consent must be obtained prior to the MR Imaging and DMSA scanning

Exclusion Criteria

1. Previous diagnosis of pyelonephritis
2. All contra-indications for undergoing MRI
3. A psychiatric, addictive, or any disorder that compromises the ability to give truly informed consent for participation in this study

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. The sensitivity, specificity, positive and negative predictive value and inter observer agreement of MRI in diagnosing acute pyelonephritis as compared to the reference standard. <br>1.1. The MRI findings will be compared to the findings at imaging of the standard diagnostic work-up that preceded MRI. The diagnostic value of specific MRI characteristics for pyelonephritis will be calculated. The value of diffusion-weighted imaging (DWI) will be analysed.

Secondary Outcome Measures

Name	Time	Method
1. To determine whether MR-diffusion weighted imaging (DWI) has additional value in the imaging of pyelonephritis<br>2. To determine whether MRI scanning can differentiate acute pyelonephritis from renal scarring