NCT01958606已完成不适用
High Intensity Interval Training in Chronic Stroke
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 18
- 试验地点
- 2
- 主要终点
- Change in Peak Aerobic Capacity (VO2-peak)
研究概览
简要总结
The objective of this study was to compare the effectiveness of high intensity interval training (HIT) and traditional aerobic training for persons with stroke.
详细描述
Participants were randomized to either HIT or traditional aerobic training; each 25 minutes, 3 times per week for 4 weeks. Outcomes were measured before and after training by a blinded rater.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 35 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age 35-90 years
- •unilateral stroke experienced >6 months prior to enrollment
- •able to walk 10m overground with assistive devices as needed and no physical assistance
- •able to walk 3 minutes on the treadmill at >.13m/s (0.3mph) with no aerobic exercise contraindications
- •stable cardiovascular condition (American Heart Association class B, allowing for aerobic capacity <6 metabolic equivalents)
- •discharged from formal rehabilitation
排除标准
- •significant resting ECG abnormalities
- •evidence of significant arrhythmia or myocardial ischemia on treadmill ECG stress test
- •hospitalization for cardiac or pulmonary disease within 3 months
- •pacemaker or implanted defibrillator
- •lower extremity claudication
- •unable to communicate with investigators or correctly answer consent comprehension questions
- •severe lower extremity spasticity (Ashworth >2)
- •lower extremity weight bearing pain >4/10 on visual analogue scale
- •For the transcranial magnetic stimulation substudy, additional exclusions will also be applied. These include large cerebral infarcts or other structural defects with the potential to increase seizure risk, uncontrolled seizures, metal implants and previous craniotomy.
结局指标
主要结局
Change in Peak Aerobic Capacity (VO2-peak)
时间窗: Baseline and 4 weeks
次要结局
- Change in Submaximal Aerobic Capacity (VO2 at Ventilatory Threshold)(Baseline and 4 weeks)
- Change in Gait Velocity (10 Meter Walk Test)(Baseline and 4 weeks)
- Change in 6-Minute Walk Test(Baseline and 4 weeks)
- Change in Gait Economy (Mean Oxygen Uptake at Comfortable Walking Speed)(Baseline and 4 weeks)
- Change in Fastest Treadmill Speed (Steep Ramp Test)(Baseline and 4 weeks)
- Change in Fractional Utilization(Baseline and 4 weeks)
研究者
Brett Kissela
Principal Investigator
University of Cincinnati
研究点 (2)
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