High Intensity Interval Training in Chronic Stroke

University of Cincinnati1 site in 1 country18 target enrollmentOctober 2013

ConditionsStroke

Overview

Phase: N/A
Intervention: Not specified
Conditions: Stroke
Sponsor: University of Cincinnati
Enrollment: 18
Locations: 1
Primary Endpoint: Change in Peak Aerobic Capacity (VO2-peak)
Status: Completed
Last Updated: 8 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The objective of this study was to compare the effectiveness of high intensity interval training (HIT) and traditional aerobic training for persons with stroke.

Detailed Description

Participants were randomized to either HIT or traditional aerobic training; each 25 minutes, 3 times per week for 4 weeks. Outcomes were measured before and after training by a blinded rater.

Registry

clinicaltrials.gov

Start Date

October 2013

End Date

August 2014

Last Updated

8 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

University of Cincinnati

Responsible Party

Principal Investigator

Brett Kissela

Principal Investigator

University of Cincinnati

Eligibility Criteria

Inclusion Criteria

•age 35-90 years
•unilateral stroke experienced \>6 months prior to enrollment
•able to walk 10m overground with assistive devices as needed and no physical assistance
•able to walk 3 minutes on the treadmill at \>.13m/s (0.3mph) with no aerobic exercise contraindications
•stable cardiovascular condition (American Heart Association class B, allowing for aerobic capacity \<6 metabolic equivalents)
•discharged from formal rehabilitation

Exclusion Criteria

•significant resting ECG abnormalities
•evidence of significant arrhythmia or myocardial ischemia on treadmill ECG stress test
•hospitalization for cardiac or pulmonary disease within 3 months
•pacemaker or implanted defibrillator
•lower extremity claudication
•unable to communicate with investigators or correctly answer consent comprehension questions
•severe lower extremity spasticity (Ashworth \>2)
•lower extremity weight bearing pain \>4/10 on visual analogue scale
•For the transcranial magnetic stimulation substudy, additional exclusions will also be applied. These include large cerebral infarcts or other structural defects with the potential to increase seizure risk, uncontrolled seizures, metal implants and previous craniotomy.

Outcomes

Primary Outcomes

Change in Peak Aerobic Capacity (VO2-peak)

Time Frame: Baseline and 4 weeks

Secondary Outcomes

Change in Submaximal Aerobic Capacity (VO2 at Ventilatory Threshold)(Baseline and 4 weeks)
Change in Gait Velocity (10 Meter Walk Test)(Baseline and 4 weeks)
Change in 6-Minute Walk Test(Baseline and 4 weeks)
Change in Gait Economy (Mean Oxygen Uptake at Comfortable Walking Speed)(Baseline and 4 weeks)
Change in Fastest Treadmill Speed (Steep Ramp Test)(Baseline and 4 weeks)
Change in Fractional Utilization(Baseline and 4 weeks)