Effects of Aerobic Interval Training on Cardiac Function, With Special Focus on Pulmonary Pressures and Right Sided Function, in Patients With Chronic Obstructive Pulmonary Disease and Hypoxemia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 16
- 试验地点
- 1
- 主要终点
- Pulmonary artery pressure
研究概览
简要总结
Patients with severe Chronic Obstructive Pulmonary Disease (COPD) and low oxygen levels in the blood are at risk of developing pulmonary hypertension and strain on the right side of the heart, both of which are known to increase symptoms and worsen prognosis It is not fully established whether interval exercise training in patients with severe COPD and concomitant low oxygen levels is beneficial.
This study aims to evaluate the effects of aerobic interval exercise training in patients with severe COPD and low oxygen levels in the blood, with a particular emphasis on such effects on the cardiovascular system and pulmonary circulation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 45 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Chronic Obstructive Pulmonary Disease (COPD)
- •Forced Expiratory Volume 1 second (FEV1) <60% of predicted
- •FEV1%FVC <70 % of predicted (FVC = Forced Vital Capacity)
- •Qualify for Long term oxygen therapy (LTOT), or presence of significant desaturation on exercise.
排除标准
- •Unstable ischaemic heart disease or valvular heart disease.
- •Active malignant disease.
- •Substance abuse.
- •Physical or mental disability that prevents participation in the exercise programme or testing.
- •Pregnancy.
- •Exacerbation of COPD or respiratory tract infection last 6 weeks before.
- •Completed pulmonary rehabilitation programme or other organised exercise programme last 3 month
- •Use of high doses of systemic steroids.
研究组 & 干预措施
exercise training
Outpatients treadmill interval training, 4x4 minutes with 3 minutes in between at lower intensity. 3 sessions weekly for 10 weeks to a total of 30 sessions.
干预措施: Exercise (Other)
结局指标
主要结局
Pulmonary artery pressure
时间窗: Change from baseline at 10 weeks
Examined by right heart catheterisation
次要结局
未报告次要终点