Maternal Periodontal Status and Cytokines in Preeclampsia

Completed

• Conditions: Periodontal Diseases; Preeclampsia
• Interventions: Diagnostic Test: gingival crevicular fluid collection

• Registration Number: NCT03088228
• Lead Sponsor: Hacer Sahin Aydinyurt

Brief Summary

Background: The purpose of this study is to examine the relationship between maternal preeclampsia and periodontal parameters and the correlation of these two disorders with maternal gingival crevicular fluid levels (GCF) of interleukin (IL)-35, interleukin-37 and interleukin-6. The investigators also investigated their relation to the severity of preeclampsia.

Methods: 82 preeclamptic women were recruited to the study (29 healthy pregnant women, 30 mild preeclamptic patient, 23 severe preeclamptic patient ). The clinical periodontal parameters and GCF samples were collected in the first day of puerperium.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-02-02
• Primary Completion: 2016-08-15
• Study Completion: 2016-12-31
• Study First Submitted: 2017-02-16
• Study First Submitted QC: 2017-03-22
• Study First Posted: 2017-03-23
• Status Verified: 2017-09
• Last Update Submitted: 2017-09-26
• Last Update Posted: 2017-09-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 80

Inclusion Criteria

• Aged between 18 and 45 years
• 25 and 40 weeks of gestation.
• Healthy pregnants, mild and severe preeclampsia

Exclusion Criteria

• Patients with accompanying diseases
• multiple gestations
• congenital abnormalities were excluded from the study.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
healthy pregnants	gingival crevicular fluid collection	-

Primary Outcome Measures

Name	Time	Method
maternal periodontal clinical parameters and IL-37 and IL-35 and IL-6 levels	6 months	IL-37 IL-35 and IL-6 levels in maternal gingival crevicular fluid levels between the three groups