Effect-site Concentration of Remifentanil for Double-lumen Tubes Intubation: Airtraq VS Macintosh Laryngoscope

Not Applicable

Completed

• Conditions: Hemodynamic Instability; Intubation Complication

• Registration Number: NCT03653910
• Lead Sponsor: Huazhong University of Science and Technology

Brief Summary

The 50% effective concentration of remifentanil by target controlled infusion was not determined for inhibiting the haemodynamic response during double-lumen tube (DLT) intubation. Previous study showed that Airtraq videolaryngoscope provided more stable haemodynamics than Macintosh for double-lumen tube intubation. In this study, the investigators will compare the 50% effective concentration of remifentanil between Airtraq videolaryngoscope and Macintosh laryngoscope for inhibiting haemodynamic responses during DLT intubation.

Detailed Description

Dixon "up-and-down" method was used to determine 50% effective concentration of remifentanil by target controlled infusion for inhibiting the haemodynamic responses during DLT intubation with Airtraq videolaryngoscope or Macintosh laryngoscope.

Study Timeline

• Study First Submitted: 2018-08-06
• Study First Submitted QC: 2018-08-29
• Study First Posted: 2018-08-31
• Study Start: 2018-09-03
• Status Verified: 2019-05
• Primary Completion: 2019-05-10
• Study Completion: 2019-05-17
• Last Update Submitted: 2019-05-18
• Last Update Posted: 2019-05-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 62

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Remifentanil TCI effect site concentration	through study completion, an average of 20 min	preestablish remifentanil TCI effect site concentration(ng/ml)

Secondary Outcome Measures

Name	Time	Method
Narcotrend index	at entering the operation room(T1), at immediately before DLT intubation(T2), at immediately after DLT intubtion(T3), at 1 minute(T4)/2 minutes (T5)/3 minutes(T6) after DLT intubation	Narcotrend index in Arabic numerals
mean arterial pressure	at entering the operation room(T1), at immediately before DLT intubation(T2), at immediately after DLT intubtion(T3), at 1 minute(T4)/2 minutes (T5)/3 minutes(T6) after DLT intubation	mean arterial pressure in mmHg
heart rate	at entering the operation room(T1), at immediately before DLT intubation(T2), at immediately after DLT intubtion(T3), at 1 minute(T4)/2 minutes (T5)/3 minutes(T6) after DLT intubation	heart rate in bpm

Trial Locations

Locations (1)

Tongji Hospital, Huazhong University of Science and Technology; 🇨🇳 Wuhan, Hubei, China