Epidemiology of Barrett's Esophagus: A Population Based Study

Mayo Clinic1 site in 1 country534 target enrollmentJanuary 2010

ConditionsBarrett's Esophagus Gastroesophageal Reflux Disease (GERD)Olmsted County Resident

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Barrett's Esophagus
Sponsor: Mayo Clinic
Enrollment: 534
Locations: 1
Primary Endpoint: The primary outcome from the survey will be the proportion of patients willing to undergo an esophageal capsule study compared to those willing to undergo an endoscopic procedure (Esophagogastroduodenoscopy or transnasal endoscopy)
Status: Completed
Last Updated: 12 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

To assess attitudes toward screening for esophageal adenocarcinoma (EAC) and Barrett's esophagus (BE) in the community.

To develop a population based clinical risk factor prediction model for the diagnosis of BE and identify novel risk factors for BE which would make population based screening more efficient. This will be an important first step in identifying the target population for BE screening, another crucial component of making screening feasible and efficient

Registry

clinicaltrials.gov

Start Date

January 2010

End Date

June 2011

Last Updated

12 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

Mayo Clinic

Responsible Party

Principal Investigator

Prasad G. Iyer

Mayo Clinic

Eligibility Criteria

Inclusion Criteria

•Case: Olmsted county residents \> 18 years old from the barrett's esophagus (BE) incidence cohort who are still alive at the time of study.
•Control # 1 : Olmsted county residents \> 18 years old that responded to a recent community based survey and reported gastroesophageal reflux (GER) symptoms at least once a week and without a known diagnosis of BE.
•Control # 2 : Olmsted county residents \> 18 years old that responded to a recent community based survey that did not report any GER symptoms and without a known diagnosis of BE.

Exclusion Criteria

•Cases: BE subjects who
•Have died prior to the start of this study;
•Refuse to participate;
•Controls: respondents to the "constipation survey" who
•Are known to have BE;
•Have died prior to the start of this study;
•Refuse to participate; -

Outcomes

Primary Outcomes

The primary outcome from the survey will be the proportion of patients willing to undergo an esophageal capsule study compared to those willing to undergo an endoscopic procedure (Esophagogastroduodenoscopy or transnasal endoscopy)

Time Frame: 18 months

Secondary Outcomes

Study established (age, gender, ethnicity, reflux) and potential risk factors (sleep apnea, visceral adiposity, Helicobacter pylori infection, Metabolic Syndrome)to develop a clinical risk factor model for diagnosis of Barrett's esophagus(BE).(18 months)