eft Atrial Structure and Function in Embolic Stroke of Undetermined Source compared with Atrial Fibrillation (ES-AF)

Not Applicable

Recruiting

• Conditions: Stroke; Atrial Fibrillation; Stroke - Ischaemic; Cardiovascular - Other cardiovascular diseases

• Registration Number: ACTRN12623000411640
• Lead Sponsor: niversity of Adelaide

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-04-26
• Last Update Posted: 1 May 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

At least 18 years old
Embolic Stroke of Undetermined Source (ESUS) subgroup - history of ESUS
Atrial Fibrillation (AF) subgroup - history of AF
Comparison group - no history of either of these conditions (AF or ESUS)

Exclusion Criteria

• Age > 85 years
• Pregnancy or planned pregnancy within the next 24 months
• Unable to undergo MRI scan
• Major Surgery <6 months
• Valvular Disease Needing Intervention
• LVEF equal to or less than 35%
• Active Malignancy
• Autoimmune or Systemic Inflammation
• Specific Stroke Mechanisms: Patent Foramen Ovale, Vessel Dissection, Subacute Bacterial Endocarditis • Severe Renal Dysfunction (defined as dialysis, prior or planned transplant, Cr >2.26 mg/dl or > 200 µmol/L)
• Severe Liver Dysfunction (Cirrhosis or Bilirubin > 2 x Normal or AST/ALT/ALP > 3x Normal)
• Malabsorption Disorders
• Institutional Living
• Inability to Attend Appointments
• Inability to Provide Informed Consent

Study & Design

• Study Type: Observational
• Study Design: Not specified