Effects of Resistance Training on Physical Activity in Daily Life and Functional Capacity in Hemodialysis Patients

Not Applicable

• Conditions: Renal Insufficiency, Chronic
• Interventions: Other: Resistance Exercise Program

• Registration Number: NCT02651025
• Lead Sponsor: Federal University of Juiz de Fora

Brief Summary

The purpose of this study is to determine whether a supervised resistance exercise training during hemodialysis is effective to increase physical activity in daily life in patients with end stage renal disease.

Detailed Description

The patients will be randomized into two groups: intervention and control groups. Patients in the intervention group will receive a supervised resistance exercise training, during hemodialysis, three times/week for 12 weeks, and patients allocate to the control group will received a passive stretching program during the same timeframe.

Study Timeline

• Status Verified: 2016-01
• Study Start: 2016-01
• Study First Submitted: 2016-01-07
• Study First Submitted QC: 2016-01-07
• Last Update Submitted: 2016-01-07
• Study First Posted: 2016-01-08
• Last Update Posted: 2016-01-08
• Primary Completion: 2017-01
• Study Completion: 2017-03

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 29

Inclusion Criteria

• Patients with end stage renal disease on hemodialysis for at least three months
• Sedentary for at least six months

Exclusion Criteria

• Presence of physical limitations that prevent the implementation of physical tests
• Presence of severe comorbidity and unstable (unstable angina, decompensated heart failure, myocardial infarction history of the past six months, cardiac arrhythmias, uncontrolled hypertension with systolic blood pressure ≥ 200 mmHg and / or diastolic blood pressure ≥ 120 mmHg, diabetes decompensated, severe lung disease, acute systemic infection as well as neurological disorders, musculoskeletal and osteoarticular or other disabling conditions according to the clinical judgment)
• Hospitalization in the three months prior to study entry

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Resistance Exercise Program	Resistance Exercise Program	Patients included in intervention group will submit to resistance exercise training during hemodialysis, three times a week, for twelve weeks. This program includes exercises for the upper and lower limbs.

Primary Outcome Measures

Name	Time	Method
Physical Activity in Daily Life	12 weeks	The physical activity in daily life will be estimated as the mean number of steps using a triaxial accelerometer.

Secondary Outcome Measures

Name	Time	Method
Muscle function	12 weeks	The muscle function will be assessed by electromyography.
Muscle strength	12 weeks	The measurement of maximal voluntary strength of handgrip will be assessed by hydraulic model of dynamometer.
Functional capacity	12 weeks	The functional capacity will be assessed by six-minute walking test.
Depression and anxiety	12 weeks	Depression and anxiety will be assessed by the Hospital Anxiety and Depression Scale.
Quality of life	12 weeks	The quality of life will be assessed by the 36-Item Short Form Health Survey (SF36).

Trial Locations

Locations (1)

University Hospital of the Federal University of Juiz de Fora; 🇧🇷 Juiz de Fora, Minas Gerais, Brazil