Pharmacodynamic interaction between remimazolam and remifentanil during anesthesia induction - randomized trial

Not Applicable

Recruiting

• Conditions: ot limited

• Registration Number: JPRN-jRCTs031230301
• Lead Sponsor: Masui Kennichi

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-08-21
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

(1) Patients aged between 18 and 89 years undergoing general anesthesia for elective surgery at Yokohama City University Hospital
(2) Patients who have an arterial catheter inserted into the radial artery for intraoperative and postoperative blood pressure measurements or blood sampling
(3) Patients who have given written consent to participate in this study

Exclusion Criteria

Patients for whom remimazolam, remifentanil, and rocuronium are contraindicated in the Japanese package inserts; patients receiving benzodiazepines for >=1 week within 3 months; patients with a history of drug dependence; organic brain disease; pregnant and lactating women; American Society of Anesthesiologists physical status is >=3; body mass index >=30 kg/m2; Glasgow coma scale <15; or patients deemed ineligible by the study physician

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Remimazolam and remifentanil effect-site concentrations at loss of consicousness, and to suppress the sympathetic response to laryngoscopy and tracheal intubation

Secondary Outcome Measures

Name	Time	Method
Electroencephalogram monitoring, invasive arterial blood pressure , heart rate, and effect-site concentrations fof remimazolam and remifentanil