Coronary Disease and the Effect of High-intensity Interval Training
Not Applicable
Completed
- Conditions
- Coronary Disease
- Interventions
- Behavioral: high intensity interval-based aerobic exerciseOther: Usual care
- Registration Number
- NCT02494947
- Lead Sponsor
- Norwegian University of Science and Technology
- Brief Summary
The primary purpose of this study is to investigate if systematic, high intensity, interval-based aerobic exercise training results in regression of lipid content of atherosclerotic coronary artery plaques, and in reduction of plaque burden in patients with stable coronary heart disease. Composition and morphologic characteristics of plaques will be studied by intra-coronary near-infrared spectroscopy (NIRS) and intravascular ultrasound (IVUS) in patients undergoing percutaneous coronary intervention.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
- stable coronary artery disease
- will undergo cardiac catheterization
- will be treated with percutaneous coronary intervention (PCI)
- signed written informed consent
- able to execute the intervention
Exclusion Criteria
- earlier bypass surgery
- known inflammatory disease other than atherosclerosis
- planned surgery within 4 months
- included in another randomized controlled study
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description interval training Usual care high intensity interval-based aerobic exercise controls Usual care usual care interval training high intensity interval-based aerobic exercise high intensity interval-based aerobic exercise
- Primary Outcome Measures
Name Time Method lipid content of atherosclerotic coronary artery plaques 6 months Lipid core burden index (LCBI) measured by intracoronary near-infrared spectroscopy
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
St Olavs Hospital
🇳🇴Trondheim, Norway