Study on Biomarkers of Postoperative Delirium in Elderly Cardiac Surgery Patients
Recruiting
- Conditions
- Delirium
- Registration Number
- NCT06194474
- Lead Sponsor
- Jining First People's Hospital
- Brief Summary
To evaluate the relationship between abnormal protein or metabolite expression levels in peripheral blood and postoperative delirium in elderly patients undergoing cardiac surgery.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 24
Inclusion Criteria
- patients between 55 and 80 years old,
- American Society of Anesthesiologists (ASA) physical status of II-III and New York Heart Association grade of II-III.
- The planned cardiac surgery.
- Hospitalization duration not less than 5 days.
- The anesthesia time will be no less than 2 hours.All patients had a normal ability to hear, read and cooperate with neuropsychological tests.
Exclusion Criteria
- The pre-operative Montreal Cognitive Assessment (MoCA) score was less than 25,
- Patients with dementia, history of neurological or psychiatric disease, hospital with anxiety depression scale (HADS) over eight points,
- Currently use sedatives or antidepressants, Patients with substance dependence on drugs or alcohol.
- Patients with liver and kidney dysfunction, patients with a history of cardiac surgery.
- Admitted to the ICU for more than two days within the month preceding the current surgery,
- Unable to cooperate with researcher's investigations.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Proteomics 1 month Proteomic data will be obtained by LC-MS/MS Analysis-DIA(Data Independent Acquisition) platform
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Fuhui Yan
🇨🇳Jining, Shandong, China