Biochemical Predictors of Delirium in Cardiac Surgery
- Conditions
- Postoperative Delirium
- Interventions
- Diagnostic Test: Metabolomic analysis
- Registration Number
- NCT03931499
- Lead Sponsor
- Meshalkin Research Institute of Pathology of Circulation
- Brief Summary
Delirium is a common neurologic complication after cardiac surgery occuring in 30-50% of patients. The occurence of this complication is associated with worse outcomes, including prolonged length of stay in the ICU and hospital, increased morbidity and mortality. Considering great clinical significance of this complication, the search for early predictors of postoperative delirium remains an urgent task. The purpose of this prospective observational study is to test the hypothesis that metabolomic changes before and after cardiac surgery could be served as early predictors of this complication.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 100
- surgery under cardiopulmonary bypass
- Age > 60 years
- CABG surgery or valve surgery (repair/replacement)
- urgent surgery
- surgery on aorta
- combined procedures (CABG+valves)
- significant stenosis of carotid arteries
- Parkinson's disease
- liver cirrhosis
- use of anticholinergic drugs, antidepressants, antiepileptic or chemotherapy drugs
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Study cohort Metabolomic analysis Patients undergoing surgery under cardiopulmonary bypass
- Primary Outcome Measures
Name Time Method Postoperative delirium 5 days after surgery Postoperative delirium will be diagnosed with CAM-ICU (confusion assessment method - intensive care unit)
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
E. Meshalkin National Medical Research Center
🇷🇺Novosibirsk, Russian Federation