NCT06194474招募中不适用
Study on Biomarkers of Postoperative Delirium in Elderly Cardiac Surgery Patients
Jining First People's Hospital1 个研究点 分布在 1 个国家目标入组 24 人开始时间: 2022年9月5日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 24
- 试验地点
- 1
- 主要终点
- Proteomics
研究概览
简要总结
To evaluate the relationship between abnormal protein or metabolite expression levels in peripheral blood and postoperative delirium in elderly patients undergoing cardiac surgery.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 55 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients between 55 and 80 years old,
- •American Society of Anesthesiologists (ASA) physical status of II-III and New York Heart Association grade of II-III.
- •The planned cardiac surgery.
- •Hospitalization duration not less than 5 days.
- •The anesthesia time will be no less than 2 hours.All patients had a normal ability to hear, read and cooperate with neuropsychological tests.
排除标准
- •The pre-operative Montreal Cognitive Assessment (MoCA) score was less than 25,
- •Patients with dementia, history of neurological or psychiatric disease, hospital with anxiety depression scale (HADS) over eight points,
- •Currently use sedatives or antidepressants, Patients with substance dependence on drugs or alcohol.
- •Patients with liver and kidney dysfunction, patients with a history of cardiac surgery.
- •Admitted to the ICU for more than two days within the month preceding the current surgery,
- •Unable to cooperate with researcher's investigations.
结局指标
主要结局
Proteomics
时间窗: 1 month
Proteomic data will be obtained by LC-MS/MS Analysis-DIA(Data Independent Acquisition) platform
次要结局
未报告次要终点
研究者
Fuhui Yan
Study Director
Jining First People's Hospital
研究点 (1)
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