Biochemical Predictors of Delirium in Patients Undergoing Cardiac Surgery Under Cardiopulmonary Bypass
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Postoperative delirium
研究概览
简要总结
Delirium is a common neurologic complication after cardiac surgery occuring in 30-50% of patients. The occurence of this complication is associated with worse outcomes, including prolonged length of stay in the ICU and hospital, increased morbidity and mortality. Considering great clinical significance of this complication, the search for early predictors of postoperative delirium remains an urgent task. The purpose of this prospective observational study is to test the hypothesis that metabolomic changes before and after cardiac surgery could be served as early predictors of this complication.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 60 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •surgery under cardiopulmonary bypass
- •Age > 60 years
- •CABG surgery or valve surgery (repair/replacement)
排除标准
- •urgent surgery
- •surgery on aorta
- •combined procedures (CABG+valves)
- •significant stenosis of carotid arteries
- •Parkinson's disease
- •liver cirrhosis
- •use of anticholinergic drugs, antidepressants, antiepileptic or chemotherapy drugs
结局指标
主要结局
Postoperative delirium
时间窗: 5 days after surgery
Postoperative delirium will be diagnosed with CAM-ICU (confusion assessment method - intensive care unit)
次要结局
未报告次要终点