Biochemical Predictors of Delirium in Patients Undergoing Cardiac Surgery Under Cardiopulmonary Bypass
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Postoperative Delirium
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- Postoperative delirium
- Last Updated
- 5 years ago
Overview
Brief Summary
Delirium is a common neurologic complication after cardiac surgery occuring in 30-50% of patients. The occurence of this complication is associated with worse outcomes, including prolonged length of stay in the ICU and hospital, increased morbidity and mortality. Considering great clinical significance of this complication, the search for early predictors of postoperative delirium remains an urgent task. The purpose of this prospective observational study is to test the hypothesis that metabolomic changes before and after cardiac surgery could be served as early predictors of this complication.
Investigators
Eligibility Criteria
Inclusion Criteria
- •surgery under cardiopulmonary bypass
- •Age \> 60 years
- •CABG surgery or valve surgery (repair/replacement)
Exclusion Criteria
- •urgent surgery
- •surgery on aorta
- •combined procedures (CABG+valves)
- •significant stenosis of carotid arteries
- •Parkinson's disease
- •liver cirrhosis
- •use of anticholinergic drugs, antidepressants, antiepileptic or chemotherapy drugs
Outcomes
Primary Outcomes
Postoperative delirium
Time Frame: 5 days after surgery
Postoperative delirium will be diagnosed with CAM-ICU (confusion assessment method - intensive care unit)