Role of Cerebral Oximetry In Reducing Delirium After Complex Cardiac Surgery
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Cardiac Disease
- Sponsor
- University Health Network, Toronto
- Enrollment
- 250
- Locations
- 1
- Primary Endpoint
- Number of patients who suffer from delirium postoperatively
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
Delirium after cardiac surgery is reported in a range of 3-47% of patients. Delirium is a serious complication that results in prolonged length of stay, increased health care costs and is associated with higher death rates. The exact cause involved in the development of delirium after cardiac surgery is unclear. The latest advancement in near-infrared spectroscopy (NIRS) Oximetry offers real-time management of patients at risk of brain injury. This approved device will monitor cerebral oxygenation during and 24hr after cardiac surgery, recording oxygenation in real time allowing the clinical team the opportunity to intervene early to prevent ischemia and possibly preventing untoward events. Adverse events followed include, but are not limited to, stroke, (transient ischemic attacks), heart attack, (myocardial infarction), clots found in lungs (pulmonary embolism), kidney failure, pneumonia, cause of death for 30-days after surgery (all cause mortality).
Hypothesis: Perioperative restoration of rSO2 desaturation to baseline values results in lower delirium rates after complex cardiac surgery.
Investigators
Eligibility Criteria
Inclusion Criteria
- •age \> 60 years
- •combined valve and CABG
- •repeat cardiac surgery
- •multiple valve replacement or repair
- •surgery of ascending aorta and aortic arch
- •signed informed consent.
Exclusion Criteria
- •cardiac surgery without the use of cardiopulmonary bypass
- •symptomatic cerebrovascular disease,
- •history of delirium, or
- •schizophrenia
Outcomes
Primary Outcomes
Number of patients who suffer from delirium postoperatively
Time Frame: Delirium we be assessed postoperatively for 7 days or Discharge
Delirium assessment CAM-ICU preoperatively (baseline) and postoperatively once a day during the first 7 postoperative days or until discharge.