Nonverbal Communication in Aged People With and Without Neurodegenerative Disease: Study of Sensorimotor Synchronization to Music
Overview
- Phase
- Not Applicable
- Sponsor
- University Hospital, Lille
- Enrollment
- 240
- Locations
- 1
- Primary Endpoint
- measure of consistency (oppositive of variability)
Overview
Brief Summary
Musical interventions improve the emotional state of patients with Alzheimer's disease (AD) while having a positive impact on the caregiver's well-being. However, the factors that could be responsible for this positive effect remain unknown. Among these, the sensory-motor synchronization (SMS) of movements to the musical rhythm, frequently observed during musical activities and possible up to the advanced stages of AD, could modulate the emotional state. Several recent studies have shown that rhythmic training (or SMS) influences the organism at the motor, cognitive and social levels while activating the cerebral reward circuit. This action that generates pleasure also facilitates non-verbal emotional expression. However, the conditions that modulate SMS and their relationship to nonverbal communication, emotional, behavioral and cognitive state have not yet been studied in healthy or pathological elderly.
Study Design
- Study Type
- Interventional
- Allocation
- Non Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Other
- Masking
- None
Eligibility Criteria
- Ages
- 60 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Cases : Patients with neurodegenerative disease (AD or related disease)
- •Native French Language
- •Corrected auditory and/or visual deficiency
- •Right-handed
- •Image rights consent signed by the patient Controls: People with no neuropathological disease
- •Native French Language
- •Corrected auditory and/or visual deficiency
- •Right-handed
- •Image rights consent signed by the control
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
measure of consistency (oppositive of variability)
Time Frame: Baseline, before SMS task
measure of consistency (oppositive of variability) of the response corresponding to the length of a vector going from 0 (bad) to 1(very good response). This measure is completed by another measure of asynchrony.
measure of asynchrony.
Time Frame: Baseline, before SMS task
The asynchrony assess the accuracy of the movements in ms. If the participant anticipated the tap relative to the musical beat, the value is negative, if the participant delayed the tap, the value is positive. A perfect tap is 0 in this case
Secondary Outcomes
- Measurement of the Music Balance Board (cf. primary outcome) during music in the presence of a real experimenter(Baseline, before SMS task)
- Measurement of the Music Balance Board (cf. primary outcome) during music in the presence of a virtual experimenter;(after SMS task, an average after 45 min)
- Measurement of the Music Balance Board (cf. primary outcome) during metronome in the presence of a real experimenter(after SMS task, an average after 45 min)
- STAI Anxiety Scale Score(through study completion, an average of 2 hours)
- Scale of Instrumental Activities of Daily Living(through study completion, an average of 2 hours)
- mini-mental state examination (MMSE) score(through study completion, an average of 2 hours)
- Measurement of the Music Balance Board (cf. primary outcome) during metronome in the presence of a virtual experimenter.(after SMS task, an average after 45 min)
- Decoding of non-verbal behaviors during the synchronization task(after SMS task, an average after 45 min)
- Intensity of body movements (quantity of motion)(after SMS task, an average after 45 min)
- Decoding of the frequency (number of behaviors / duration of the condition) of the facial expressions(through study completion, an average of 2 hours)
- Scale of Assessment of Daily Activities(through study completion, an average of 2 hours)
- Concentration of cortisol from saliva samples(Once, at Day 1, baseline)
- Neuropsychiatric Inventory (NPI) subscales Impact on the workload of the caregiver.(through study completion, an average of 2 hours)