Impact of Muscle Fat Accumulation on the Genomic Profile of Skeletal Muscle in Older Adults

Completed

• Conditions: Intermuscular Adipose Tissue Quantification

• Registration Number: NCT02187965
• Lead Sponsor: Purdue University

Brief Summary

Subjects were asked to come to the Purdue facilities after an overnight fast on 2 different testing days for 2.5 hours each day. On one day the subjects participated in blood pressure and body weight measurements as well as a muscle biopsy from the thigh. On the second day the subjects underwent an MRI and MRS scan of the thigh and calf.

Detailed Description

Not available

Study Timeline

• Status Verified: 2011-08
• Study Start: 2011-08
• Primary Completion: 2012-08
• Study Completion: 2012-08
• Study First Submitted: 2014-07-09
• Study First Submitted QC: 2014-07-10
• Last Update Submitted: 2014-07-10
• Study First Posted: 2014-07-11
• Last Update Posted: 2014-07-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 11

Inclusion Criteria

• 60-80 years old, men and women, normal body weight or obese,

Exclusion Criteria

• Certain medical conditions could have placed them at risk

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
MRI	1 day	To determine the within day reproducibility of MRI scans for intermuscular adipose tissue (IMAT) quantification in older men and women.

Secondary Outcome Measures

Name	Time	Method
genomic profile	1 day	To examine the influence of IMAT accumulation on the genomic profile of skeletal muscle of normal weight or obese adults.

Trial Locations

Locations (1)

Purdue University; 🇺🇸 West Lafayette, Indiana, United States