A Phase IIb, Double-blind, Randomised, Active-controlled, Multi-centre, Non-inferiority Trial Followed by a Phase III, Single-arm, Open-label Trial, to Assess Immunogenicity and Safety of a Booster Vaccination With a Recombinant Protein RBD Fusion Dimer Candidate (PHH-1V) Against the Virus That Cause COVID-19, Know as Severe Acute Respiratoy Syndrome Coronavirus 2 (SARS-CoV-2)SARS-CoV-2, in Adults Fully Vaccinated Against COVID-19 Followed by an Extension Period to Study a Fourth Dose Administration of PHH-1V.
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 发起方
- 入组人数
- 887
- 试验地点
- 10
- 主要终点
- Safety and tolerability of PHH-1V as third or fourth dose
研究概览
简要总结
This Phase IIb clinical study aims to compare the immunogenicity and safety of a booster dose of recombinant protein RBD fusion dimer vaccine as a heterologous booster (to subjects who have received the second dose of the Pfizer-BioNTech (Comirnaty) COVID-19 vaccine at least 182 days prior to the booster dose in this study) versus a homologous booster (subjects who received the second dose of the Comirnaty COVID-19 vaccine at least 182 days prior to the booster dose in this study) will receive a third dose of the Comirnaty vaccine).
The extension part of the study aims to compare the immunogenicity and safety of a fourth dose of PHH-1V in subjects with a primovaccination with Pfizer-BioNTech (Comirnaty) COVID-19 vaccine plus either a booster dose of Comirnaty or PHH-1V versus those with three vaccinations of Comirnaty.
详细描述
The study population includes 1075 healthy adults aged above 18 years old who have received two doses of the Comirnaty vaccine, and are at least 182 days and less than 365 days after their second dose will be randomly assigned to two treatment arms. In each arm, volunteers will be randomized in a ratio Test vaccine:Comirnaty of 2:1. Each participant will receive one booster immunisation and will be followed for 1 year to evaluate immunogenicity response and assess the safety of the test vaccine in comparison to Cominarty.
The study population of the extension part includes 200 healthy adults abode 18 years old who have received or: 3 doses of Comirnaty vaccine, or 2 doses of Comirnaty + 1 dose of PHH-1V. Each participant will receive one dose of PHH-1V.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
盲法说明
Subjects and the clinical study team will remain blinded to treatment allocation. Clinical staff involved in study drug preparation and administration will be aware of which vaccine the subject is receiving. The extension of the fourth dose will be unblinded.
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Part A: Inclusion Criteria:
- •Male or female, by birth, ≥ 18 years old at Screening.
- •Willing and able to comply with scheduled visits, laboratory tests, complete diaries, and other study procedures.
- •Body Mass Index (BMI) between 18 to 40 kg/m
- •Has received a complete COVID-19 vaccination programme (two administrations, prime and boosting) at least 182 days and with a maximum of 365 days before Screening with Comirnaty vaccine.
- •Has a negative COVID-19 polymerase chain reaction (PCR) test at Screening.
- •Willing to avoid all other vaccines within 4 weeks before and after vaccination in this study (Day 0). Seasonal influenza vaccination is allowed if it is received at least 14 days before or after vaccination.
- •Willing to refrain from blood donation during the study.
- •Women of childbearing potential must have a negative urine pregnancy test at Screening and prior to vaccination.
- •Women of childbearing potential must be willing to use highly effective contraceptive methods or have practiced sexual abstinence from the screening visit until 8 weeks after the vaccination.
- •Males who are not sterilised, must be willing to avoid impregnating female partners from Screening until 8 weeks after vaccination.
- •Willing and able to provide written informed consent prior the initiation of any study procedures.
排除标准
- •Pregnant or lactating or intending to become pregnant or plans to breastfeed during the study.
- •Positive pregnancy test at Screening or vaccination day.
- •Any medical disease (acute, subacute, intermittent, or chronic) or condition that in the opinion of the Investigator compromises the subject's safety, preclude vaccination or compromises interpretation of the results.
- •Ongoing serious psychiatric condition likely to affect participation in the study (e.g., ongoing severe depression, recent suicidal ideation, bipolar disorder, personality disorder, alcohol and drug dependency, severe eating disorder, psychosis, use of mood stabilisers or antipsychotic medication).
- •History of respiratory disease (e.g., chronic obstructive pulmonary disease [COPD]) requiring daily medications currently or any treatment of respiratory disease exacerbations (e.g., asthma exacerbation) in the last 6 months.
- •History of significant cardiovascular disease (e.g., congestive heart failure, cardiomyopathy, ischemic heart disease) or history of myocarditis or pericarditis as an adult. Controlled hypertension will be permitted at the discretion of the Investigator.
- •History of neurological or neurodevelopmental conditions (e.g., epilepsy, stroke, seizures in the last 3 years, encephalopathy, focal neurologic deficits, Guillain-Barré syndrome, encephalomyelitis, or transverse myelitis).
- •Ongoing malignancy or recent diagnosis of malignancy in the last five years excluding basal cell and squamous cell carcinoma of the skin, which are allowed.
- •Any confirmed or suspected autoimmune, immunosuppressive or immunodeficiency disease/condition (iatrogenic or congenital), including human immunodeficiency virus (HIV) infection, asplenia, or recurrent severe infections.
- •Acute illness within 72 hours before vaccination day that, in the opinion of the Investigator may interfere the evaluation of safety parameters.
- •Received investigational drug within 90 days before Screening or plans to participate in another interventional clinical study (drug/biologic/device) within 12 months after vaccination.
- •History of hypersensitivity or severe allergic reactions, including anaphylaxis, generalised urticarial, angioedema and other significant reactions related to food, drugs, vaccines, or pharmaceutical agents, which are likely to be exacerbated by any component of the COVID-19 vaccine HIPRA.
- •Use of any immunosuppressant, glucocorticoids, or other immune-modifying drugs within 2 months before vaccination day; or anticipation of the need for immunosuppressive treatment within 182 days after vaccination.
- •Received immunoglobulin, blood-derived products, or other immunosuppressant drugs within 90 days before vaccination (Day 0).
- •Known disturbance of coagulation (iatrogenic or congenital) or blood dyscrasias.
- •Known bleeding disorder (e.g., factor deficiency, coagulopathy, or platelet disorder), (iatrogenic or congenital), blood dyscrasias, or prior history of significant bleeding or bruising following intramuscular (IM) injections or venepuncture.
- •Chronic liver disease.
- •Positive test for HIV types 1 or 2 infection, hepatitis B surface antigen (HBsAg), or hepatitis C virus antibodies (HCV Abs) at Screening.
- •Suspected or known current alcohol abuse or any other substances abuse (except tobacco).
- •History of COVID-19 infection.
- •Ever been included in a trial with an experimental vaccine against COVID-
- •Close contact with anyone known to have SARS-CoV-2 infection within 15 days before Screening.
- •Scheduled elective surgery during the study.
- •Life expectancy of less than 12 months.
- •Any condition and/or laboratory finding that, in the Investigators opinion, would interfere with the study or put the subject at risk.
- •Part B (fourth dose extension): Inclusion Criteria
- •Adults ≥ 18 years old at Day
- •Participant must provide consent indicating that she or he understands the purpose and potential risks and is willing and able to participate in this extension of the study and comply with all the study requirements and procedures.
- •Has received a primary vaccination of two doses of Comirnaty followed by a booster dose either with Comirnaty or PHH-1V. Last booster dose given between 6 and 12 months before Day
- •Has a negative Rapid Antigen Test (RAT) at Day 0 before the fourth dose administration.
- •Participants may have underlying illnesses if are stable and well-controlled.
- •Participant is willing to avoid receiving live attenuated vaccines (licensed) within 4 weeks before screening or after receiving any study vaccine, or other not live vaccines (licensed) within 14 days before and after receiving any study vaccine.
- •Participant agrees not to donate blood, blood products and bone marrow at least 12 weeks before and after vaccination
- •Contraceptive use for women of childbearing potential: hormonal, intrauterine device, vasectomized partner, sexual abstinence, condom.
- •Negative pregnancy test for WOCBP at Day
- •Contraceptive use for males: vasectomized participants, condom, sexual abstinence.
- •Part B (fourth dose extension): Exclusion Criteria
- •History of anaphylactic shock of any kind
- •History of COVID-19 infection.
- •Pregnancy or breast-feeding at screening or Day 0
- •Participant has a clinically significant acute illness or fever (temperature ≥38º C / 100.4ºF) at screening or within 48 hours prior to the planned vaccination
- •Participant had a surgery requiring hospitalization before vaccination and he/she has not received the hospital discharge at day 0
- •Participant has any active malignancy
- •Participant has ongoing severe and non-stable psychiatric condition likely to affect participation in the study
- •Participant has a problematic or risk use of substances including alcohol that can compromise the study follow-up
- •Participant has a bleeding disorder, blood dyscrasia, or continuous use of anticoagulants or has any condition that contraindicates intramuscular injections or frequent phlebotomy
- •Participant has abnormal function of the immune system as in autoimmune diseases, asplenia, recurrent infections or congenital/acquired immunodeficiency
- •Chronic or recurrent administration (during at least 14 days) of systemic immunosuppressant medication within 12 weeks preceding the planned administration of study vaccine
- •Subject has received immunoglobulins and/or blood-derived products 12 weeks prior vaccination
- •Participant received any immunotherapy (monoclonal antibodies, plasma) aimed to prevent or treat COVID-19 within 90 days preceding the planned administration of study vaccine
- 另有 3 项未显示
研究组 & 干预措施
COVID-19 Vaccine HIPRA
40 ug/0.5 ml
干预措施: COVID-19 Vaccine HIPRA (Biological)
Cominarty (Pfizer-BioNtech)
30 micrograms/dose concentrate for dispersion for injection
干预措施: Cominarty (Pfizer-BioNtech) (Biological)
结局指标
主要结局
Safety and tolerability of PHH-1V as third or fourth dose
时间窗: Days 14, 28, 182, and 364
Change from baseline in safety laboratory parameters at Days 14, 28, 182, and 364 after vaccination.
Part A: Changes of the immunogenicity against Wuhan
时间窗: 14 days
Neutralisation titre measured as inhibitory concentration 50 (IC50) for each individual sample and geometric mean titre (GMT) for treatment group comparison at Baseline and Day 14.
Part B: Changes of the immunogenicity against Omicron BA.1
时间窗: Day 14
Neutralisation titre measured as inhibitory concentration 50 (IC50) by PBNA and reported as log10 concentration for each individual sample and GMT, at Day 14 post-dose 4 of PHH-1V in cohort 2 versus post-dose 3 in cohort 2 (cohort 2 having three doses of Comirnaty + the frouth dose of PHH-1V).
Safety and tolerability of PHH-1V as third or fourth dose
时间窗: 7 days
Number, percentage, and characteristics of solicited local reactions through Day 7 after vaccination.
Safety and tolerability of PHH-1V as third or fourth dose
时间窗: 28 days
Number, percentage, and characteristics of unsolicited local and systemic adverse events (AEs) through Day 28 after vaccination.
Safety and tolerability of PHH-1V as third or fourth dose
时间窗: 364 days
Number and percentage of serious adverse events (SAEs), adverse event of special interest (AESI) and medically attended adverse events (MAAE) through Day 364.
次要结局
- Immunogenicity to the SARS-CoV-2 spike glycoprotein(Days 14, 28, 98, 182, and 364)
- T-cell mediated responses against the SARS-CoV-2 S glycoprotein at Baseline & D14.(Day 14)
- Th-1/Th-2 T-cell mediated responses against the SARS-CoV-2 S glycoprotein at Baseline & D14. Th-1/Th2(Day 14)
- Changes in immunogenicity at Baseline and Days 14, 28, 182 &364.(Days 14, 28, 98, 182 and 364)
- Changes of the immunogenicity against the Variants of Concern (VOC)(Day 14, 28, 98, 182 and 364)
- Changes of the immunogenicity against the Variants of Concern (VOC)(Day 14, 28, 98, 182, 364)