Study of the effects of different targets for perfusion pressure on tissue perfusion and oxygenation in patients suffering from septic shock - Effect of blood pressure on tissue perfusion in sepsis
- Conditions
- Septic shock
- Registration Number
- EUCTR2006-005253-30-GB
- Lead Sponsor
- Queen Mary's School of Medicine & Dentistry, University of London
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Recruiting
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
Adult patients admitted to intensive care at Barts and The London NHS Trust who require vasopressor infusion (noradrenaline) for the treatment of septic shock
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range
Exclusion Criteria
Refusal of patient’s consent or relative’s assent
Cconcurrent lithium therapy
Acute myocardial ischaemia
Acute arrhythmias
Pregnancy
Weight less than 40 kg
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Main Objective: Comparison of sublingual microvascular flow index at different mean arterial pressures;Primary end point(s): To assess the effects of different mean arterial pressure end-points for noradrenaline dose on microvascular flow using SDF imaging in addition to global cardiovascular and biochemical measurements in patients suffering from septic shock;Secondary Objective: Comparison of tissue PO2 at different mean arterial pressures<br>Comparison of cutaneous red cell flux and velocity at different mean arterial pressures<br>Comparison of cutaneous temperature at different mean arterial pressures<br>Comparison of cardiac index at different mean arterial pressures <br>Comparison of serum lactate and base excess at different mean arterial pressures<br>Comparison of urine output at different mean arterial pressures<br>
- Secondary Outcome Measures
Name Time Method