Effect of Dexmedetomidine and Propofol on Regional Cerebral Tissue Oxygen Saturation

Not Applicable

Completed

• Conditions: Regional Cerebral Tissue Oxygen Saturation
• Interventions: Drug: Propofol 10 MG/ML; Drug: Dexmedetomidine Hydrochloride 0.1 MG/ML

• Registration Number: NCT03817112
• Lead Sponsor: Ain Shams University

Brief Summary

50 patients divided into 2 groups

.Group I Dexmedetomidine infusion. Group II with Propofol infusion

Detailed Description

: 50 patients anticipated for open heart surgeries were encompassed in the study. Patients were divided into 2 groups, group P (receiving propofol) and group D (receiving dexmedetomidine) during CPB. Both groups were studied for variations in right and left rScO2 as well as postoperative cognitive dysfunction using the Mini Mental State Examination Score (MMSE) test.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2017-06-15
• Primary Completion: 2018-09-30
• Status Verified: 2019-01
• Study Completion: 2019-01-21
• Study First Submitted: 2019-01-23
• Study First Submitted QC: 2019-01-23
• Last Update Submitted: 2019-01-23
• Study First Posted: 2019-01-25
• Last Update Posted: 2019-01-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Patients undergoing valve surgeries
• Patients undergoing on pump coronary artery bypass grafting surgeries

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Exclusion Criteria

• emergency cases, patients with cervical spine pathology (cervical stenosis, cervical disc herniation, carotid stenosis), patients with cerebral pathology (cerebral strokes, ischemic attacks), patients with Mini Mental State Examination Score (MMSE) of 23 or less, complicated cases with prolongation of the cardiopulmonary bypass period, patients needing moderate hypothermia

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Propofol	Propofol 10 MG/ML	Propofol infusion
Dexmedetomidine	Dexmedetomidine Hydrochloride 0.1 MG/ML	Infusion of dexmedetomidine

Primary Outcome Measures

Name	Time	Method
cognitive function assessment	24 hours postoperative	Mini Mental State Examination Score (MMSE) test to assess orientation to time and place with ability to speak, think and draw. with highest ability 32 and lowest o

Trial Locations

Locations (1)

Ain Shams Cardiothoracic hospital; 🇪🇬 Cairo, Egypt