The Effect of Continuous Propofol Versus Dexmedetomidine Infusion on Regional Cerebral Tissue Oxygen Saturation During Cardiopulmonary Bypass
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- cognitive function assessment
研究概览
简要总结
50 patients divided into 2 groups
.Group I Dexmedetomidine infusion. Group II with Propofol infusion
详细描述
: 50 patients anticipated for open heart surgeries were encompassed in the study. Patients were divided into 2 groups, group P (receiving propofol) and group D (receiving dexmedetomidine) during CPB. Both groups were studied for variations in right and left rScO2 as well as postoperative cognitive dysfunction using the Mini Mental State Examination Score (MMSE) test.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Care Provider)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients undergoing valve surgeries
- •Patients undergoing on pump coronary artery bypass grafting surgeries
排除标准
- •emergency cases, patients with cervical spine pathology (cervical stenosis, cervical disc herniation, carotid stenosis), patients with cerebral pathology (cerebral strokes, ischemic attacks), patients with Mini Mental State Examination Score (MMSE) of 23 or less, complicated cases with prolongation of the cardiopulmonary bypass period, patients needing moderate hypothermia
研究组 & 干预措施
Dexmedetomidine
Infusion of dexmedetomidine
干预措施: Dexmedetomidine Hydrochloride 0.1 MG/ML (Drug)
Propofol
Propofol infusion
干预措施: Propofol 10 MG/ML (Drug)
结局指标
主要结局
cognitive function assessment
时间窗: 24 hours postoperative
Mini Mental State Examination Score (MMSE) test to assess orientation to time and place with ability to speak, think and draw. with highest ability 32 and lowest o
次要结局
未报告次要终点
研究者
Ayman Anis Metry
Clinical professor
Ain Shams University