Prevalence of Preoperative Dehydration in Major Elective Urologic Surgery and Its Impact on Postoperative Outcome
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 188
- 试验地点
- 1
- 主要终点
- Prevalence of Dehydration at Induction of Anesthesia
研究概览
简要总结
The primary objective of this study is to measure the prevalence of preoperative dehydration in elective major abdominal urologic surgery when we apply our daily standard operation procedures. Secondary objectives are to assess the impact of preoperative dehydration on postoperative outcome. The hypothesis is that preoperative dehydration leads to more postoperative complications.
详细描述
The information about the impact of preoperative dehydration on postoperative outcome is conflicting. One of the reported difficulties of the studies in this field is to get adequate power for statistical significance. The incidence of preoperative dehydration in different surgical populations has been reported in about one third of patients. The prevalence in the urologic population is not known.
This is a monocentric observational study with no study intervention. The goal is to consecutively include all patients undergoing major urologic surgery during 365 days who meet the inclusion criteria to assess the prevalence of preoperative dehydration in elective major abdominal urologic surgery when the standard operation procedures of the University Hospital Bern are applied.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •>18 years old
- •Major elective urologic surgery i. Prostate surgery ii. Bladder surgery iii. Kidney surgery iv. Various laparotomies / laparoscopies (e.g. retroperitoneal lymphadenectomy)
- •Standard procedure planned
- •Standard perioperative management planned
- •Informed consent
排除标准
- •Preoperative iv-fluids
- •Pregnancy (which is a contraindication to this type of surgery per se)
- •Inability to give informed consent (e.g. severe psychiatric disorder, dementia)
- •Inability to complete the Quality of Recovery (QoR) questionnaire
- •Enrolment of the investigator, his/her family members, employees and other dependent persons
结局指标
主要结局
Prevalence of Dehydration at Induction of Anesthesia
时间窗: Time point 0: time (estimated between 7am and 4pm on day of surgery) at Induction of Anesthesia for Major Urologic Surgery
Number of dehydrated patients judged by urine specific gravity, osmolality, creatinine, color.
次要结局
- Postoperative Nausea and Vomiting (PONV)(6 hours, 24 hours and 48 hours postoperatively)
- Gastrointestinal function (flatus/defecation) postoperatively(24 hours and 48 hours postoperatively)
- Complications within hospitalization(within hospital stay, expected to be within 2 weeks postoperatively)
- Quality of recovery(24 hours postoperatively)
- Renal function postoperatively(6 hours, 24 hours and 48 hours postoperatively)
- Fluid balance(within 24 hours postoperatively)