Aggressive Squamous Cell Carcinoma in Organ Transplant Recipients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- Diameter of Squamous Cell Carcinoma
研究概览
简要总结
To identify risk factors for aggressiveness in Squamous Cell Carcinoma of the skin in organ transplant recipients.
详细描述
Squamous Cell Carcinomas (SCC) are one of the most common skin cancers. They belong to the epithelial neoplasm of the skin, which manifest a local aggressive growth and have potential for metastasis. Organ transplant recipients have a hundredfold higher incidence of SCC.
Unfortunately the primary tumor, regional nodes, metastasis (TNM)-Classification for the prognosis of SCC in this group of patient has not yet been established. Therefore there are no standardised criteria for evaluation of local recurrence or prognosis.
The aim of this study is to identify criteria, which permit a risk assessment relating to aggressiveness of SCC.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Organ transplant recipients with:
- •> 9 SCC in total or
- •> 2 SCC per year (in any one year) or
- •any single "index" SCC that has a very poorly differentiated cell morphology or that behaved aggressively in Terms of local recurrence or local/systemic metastasis
排除标准
- •Non organ transplant recipients
结局指标
主要结局
Diameter of Squamous Cell Carcinoma
时间窗: 1 year
* Location * exact size in mm * histological classification (well-differentiated, moderately-differentiated, poorly differentiated, spindle cell morphology, desmoplastic, basi-squamous, acantholytic) * Invasion * rapid growth * local recurrence * sentinel node sampling * Metastasis
次要结局
- Sun exposure history(1 year)