Investigating how the physical form of food affects the absorption of contained starch and carbohydrate by the gut

Not Applicable

Completed

• Conditions: The absorption of carbohydrate from different food matrices; Oral and Gastrointestinal - Normal oral and gastrointestinal development and function

• Registration Number: ACTRN12616000291482
• Lead Sponsor: Massey University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2016-03-07
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 25

Inclusion Criteria

Female volunteers between the age of 20 and 40 years were screened by questionnaire for general medical health, gut health, ongoing consumption of medication, dietary supplements, dietary peculiarities and smoking. Inclusion criteria is as follows: (1) Participants were non-smokers with no history of gastrointestinal diseases including recent gut infection evidenced by a recent history of abdominal pain, nausea, vomiting, diarrhea, passage of blood and mucus in stools. (2) Participants were not taking any ongoing prescription or OTC medication or multivitamins except for contraceptive pills. (3) The number of Standard alcohol drinks consumed per week were calculated from results of alcohol consumption in the questionnaire to ensure that participants did not exceed a moderate alcohol intake. (4) Participants did not have high levels of endogenously produced mannitol or lactulose in the urine.

Exclusion Criteria

Participants were screened by a Health Questionnaire (attached) to determine participation in the study. Volunteers who were excluded are: Those that had high levels of endogenously produced mannitol or lactulose in the urine, smokers, exceeded the intake of one standard alcohol drink per day, had a history of gastrointestinal diseases including recent gut infection evidenced by a recent history of abdominal pain, nausea, vomiting, diarrhea, passage of blood and mucus in stools, had a history of or current urinary tract infections, vaginal conditions that cause discharge, took ongoing prescription medication, antibiotics, OTC medication or multivitamins, took prebiotic and probiotic supplements such as lactulose.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Quantification of nutrient uptake index (NUI) which represents the speed at which simple sugars are liberated from the food matrix into the lumen of the small intestine and absorbed by the mucosa. [Urine samples were collected from subjects every half-hour over a six hour period. ]

Secondary Outcome Measures

Name	Time	Method
A composite secondary outcome was to compare the rates of appearance of glucose and insulin in the systemic circulation with the rate of absorption of mannitol and lactulose to better quantify the differences in kinetics of active absorption from those of passive absorption<br>[Along with urine samples, venous blood was collected from an indwelling cannula every half-hour over four hours and then at five and six hours respectively. The temporal pattern of absorption of each of the two probe sugars and the plasma blood glucose and plasma insulin values for six hours after consumption of each food and after the control will be compared.]