Study of the Prognostic Value of Musculoskeletal Ultrasound in Adults With Chikungunya

• Conditions: Infected by Chikungunya Virus
• Interventions: Other: SF36 (QQoL)

• Registration Number: NCT02281123
• Lead Sponsor: University Hospital Center of Martinique

Brief Summary

Chikungunya is a viral disease transmitted by mosquitoes whose clinical feature is the early joint damage. Approximately 8% of patients have chronic arthropathy resembling to the rheumatoid polyarthritis. The EchoCHIK study we propose is in the context of the epidemic in Martinique which began in January 2014. It should give a better understanding of arthritis and juxtaarticular of CHIK and look for signs that may allow ultrasound predict the evolution of chronic arthropathy of CHIK.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-07
• Study First Submitted: 2014-10-29
• Study First Submitted QC: 2014-10-30
• Study First Posted: 2014-11-02
• Primary Completion: 2015-01
• Status Verified: 2015-07
• Last Update Submitted: 2015-07-27
• Last Update Posted: 2015-07-28
• Study Completion: 2016-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

1. Age at onset of symptoms ≥ 45 years
2. Seen in consultation at the University Hospital of Fort-de-France
3. Suspected chikungunya infection (fever and sudden onset of joint pain affecting the wrists, hands, ankles or knees)
4. Duration of symptoms suggestive of infection chikungunya less than or equal to 10 days
5. Presence of joint pain on the day of inclusion
6. No history of inflammatory arthritis
7. Absence of steroidal or non-steroidal anti-inflammatory drugs taken within two weeks prior to inclusion
8. Ability to participate in the study throughout its duration (12 months)
9. Patient affiliated or beneficiary of a social health care.
10. Acceptance to participate in the study and monitoring proposed and signed informed consent

Exclusion Criteria

1. Age at onset of symptoms <45 years
2. Duration of symptoms suggestive of chikungunya for more than 10 days
3. Lack of joint pain on the day of inclusion
4. History of inflammatory arthritis Nonsteroidal anti-inflammatory drugs or
5. Taking in the two weeks preceding the inclusion
6. Inability to participate in the study throughout its duration (12 months)
7. Patient is not affiliated or beneficiary of a social health care.
8. Refusal to participate in the study or to sign a consent

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patient suspected of being infected by chikungunya	SF36 (QQoL)	Patient (\>= 45 ans) suspect d'infection par le virus du chikungunya et présentant des symptomes depuis moins de 10 jours

Primary Outcome Measures

Name	Time	Method
Presence of sonographic signs observed during the initial scan: periarticular infiltration, effusion, positive Doppler, erosions.	enrollement visit	Progression to chronic form defined by the persistence or recurrence of muscle symptoms (myalgia) and joints (arthralgia, arthritis) more than two months after the onset of symptoms of acute phase.

Secondary Outcome Measures

Name	Time	Method
Presence of clinical and sonographic signs observed at each visit: arthralgia, arthritis clinics, periarticular infiltration, effusion, positive Doppler erosions.	1 month, 3 month, 6 month and 12 month after the first symptoms of infection by chikungunya virus

Trial Locations

Locations (1)

CHU de Martinique; 🇲🇶 Fort-de-France, Martinique