Effects of Aerobic Exercise with and without Cognitive Tasks on Gait control, Balance, Acetylcholine neurotransmitter Activity, activity of front part of the Brain and Symptoms of people with Parkinson´s disease

Not Applicable

Recruiting

• Conditions: Other anormalities of gait and mobility; Loss of Gait automaticity in Parkinsos´s Disease; Gait problems

• Registration Number: RBR-7t8vqrz
• Lead Sponsor: Escola de Educação Física e Esporte da Universidade de São Paulo

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2022-02-14
• Last Update Posted: 29 May 2023
• Study Completion: 2023-12-30

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

Parkinson´s disease severity at II-III stage according to the modified Hoen Yahr scale; Age between 50 and 85 years old; Global cognition with a score greater than 21 for individuals with schooling between 4 and 12 years, and greater than 20 for individuals with more than 12 years of schooling, according to the Monttreal Cognitive Assessment (MoCa), portuguese version; and being a faller (i.e., more than 2 falls in the last 6 months)

Exclusion Criteria

Not have had training in the last 6 months; No othe neurological disorder (beyond idiopathic Parkinson´s disease; Do not use AChE inhibitors (e.g., rivastigmine, donepezil, galantamine and tacrine), benzodiazepine, neuroleptic or tricyclic antidepressants; Not having resting tremor with a score greater than 2 (i.e., excessive tremor); and not present Freezing of Gait

Study & Design

• Study Type: Intervention
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Primary outcome- ET+COG will be more effective than ET alone in improving gait automaticity (our primary outcome) in people with Parkinson´s Disease (PD). Gait automaticity will be evaluated through the variability of gait parameters (most debilitating in PD) in a single task, but also in a dual task

Secondary Outcome Measures

Name	Time	Method
Secondary outcome- ET+COG will be more effective than ET alone in increase cholinergic activity (our principal secondary outcome) of people with Parkinson´s Disease. Cholinergic activity will be evaluated through Short Latency Afferent Inhibition, which is a paired pulse neurophysiological technique