The primary CNS vasculitis (PCNSV) and their differential diagnoses compared genetic background, clinical, diagnostic and therapeutic data and outcome.

Recruiting

Conditions: I67.7
I67.8
Cerebral arteritis, not elsewhere classified
Other specified cerebrovascular diseases

Registration Number: DRKS00005347

Lead Sponsor: niversitätsklinikum Essen, Institut für Transfusionsmedizin, Transplantationsdiagnostik und FuE

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 40

Inclusion Criteria

Inclusion criteria Group 1:
According to the guidelines of the DGN at least three of the four criteria listed below must be met:
- Clinical symptoms of multifocal or diffuse CNS disease with recurrent or progressive course.
- Cerebral angiography, cerebrospinal fluid and / or MRI diagnosis-that supports the diagnosis of vasculitis.
- Exclusion of an underlying systemic infection or inflammation.
- Histological evidence of parenchymal or leptomeningeal vasculitis and exclusion of infection, neoplasia or other primary vascular disease.
Inclusion criteria Group 2:
-PCNSV as a suspected disease was not confirmed by history and examination results
-Symptoms are explained by another diagnosis

Exclusion Criteria

Exclusion criteria Group 1:
- Other, symptoms explanatory disease of the CNS
- Severe organic brain syndrome with lack of capacity to consent

Study & Design

Study Type: observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The primary endpoint is the evidence or lack of an HLA association in patients with PCNSV compared to the control group. The assessment is based on laboratory results when laboratory analysis will be completed.

Secondary Outcome Measures