A Long-term Study to Evaluate Safety and Maintenance of Treatment Effect of LY3074828 in Participants With Moderate-to-Severe Plaque Psoriasis (OASIS-3)
- Registration Number
- NCT03556202
- Lead Sponsor
- Eli Lilly and Company
- Brief Summary
The purpose of this study is to evaluate the long-term safety and maintenance of efficacy of mirikizumab in participants with moderate-to-severe plaque psoriasis.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 1936
- Participant must have completed the last visit of an eligible study period of originating study.
- Participant must be willing to follow the birth control measures during and after study treatment if woman of childbearing potential.
- Participant must not have an unstable or uncontrolled illness, including but not limited to a cerebro-cardiovascular, respiratory, hepatic, renal, gastrointestinal, endocrine, hematologic, or neurologic disease or abnormal lab results, that the study investigator thinks makes it unsafe or inappropriate for the participant to participate in this study.
- Participant must not have stopped taking mirikizumab during a previous study or if the study investigator thinks restarting mirikizumab would create an unacceptable risk to the participant.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description 125 Milligram (mg) Mirikizumab Q8W Mirikizumab Participants received 125 mg mirikizumab administered subcutaneously (SC) every eight weeks (Q8W). 250 mg Mirikizumab Q8W Excluding Secukinumab Mirikizumab Participants received 250 mg mirikizumab administered SC Q8W excluding participants who received secukinumab of their originating study (AMAJ) Secukinumab/250 mg Mirikizumab Q8W Mirikizumab Participants from previous originating study \[who received secukinumab (AMAJ)\] received 250 mg mirikizumab administered SC Q8W.
- Primary Outcome Measures
Name Time Method Percentage of Participants With a Static Physician's Global Assessment Among Those Who Entered the Study With a sPGA of 0,1 Week 104 The sPGA is the physician's determination of the participant's psoriasis (PsO) lesions overall at a given time point. Lesions were categorized by descriptions for induration, erythema, and scaling. Participant's PsO was assessed as 0 (clear), 1 (minimal), 2 (mild), 3 (moderate), 4 (severe), or 5 (very severe). An sPGA responder was defined as having a post-baseline sPGA score of "0" or "1" with at least a 2-point improvement from baseline. Participants who did not meet the clinical response criteria or had missing data at Week 104 were considered non-responders for non-responder Imputation (NRI) analysis.
Percentage of Participants Who Maintained a ≥90% Improvements in Psoriasis Area and Severity Index (PASI) 90 Among Those Who Entered the Study With a PASI 90 Week 104 PASI combines the extent of body surface involvement in 4 anatomical regions (head, trunk, arms, and legs) and the severity of scaling, redness, and plaque induration/infiltration (thickness) in each region. For each region the percent area of skin involved was estimated from 0 (0%) to 6 (90%-100%) and severity was estimated by clinical signs of erythema, induration and scaling with a scores range from 0 (no involvement) to 4 (severe involvement). Each area is scored separately and the scores then combined for the final PASI. Final PASI calculated as: sum of severity parameters for each region \* area score \* weighing factor \[head (0.1), upper limbs (0.2), trunk (0.3), lower limbs (0.4)\]. Overall scores range from 0 (no PsO) to 72 (the most severe disease).
- Secondary Outcome Measures
Name Time Method Percentage of Participants Achieving a 100% Improvement in Psoriasis Area and Severity Index (PASI 100) Week 104 PASI combines the extent of body surface involvement in 4 anatomical regions (head, trunk, arms, and legs) and the severity of scaling, redness, and plaque induration/infiltration (thickness) in each region. For each region the percent area of skin involved was estimated from 0 (0%) to 6 (90%-100%) and severity was estimated by clinical signs of erythema, induration and scaling with a scores range from 0 (no involvement) to 4 (severe involvement). Each area is scored separately and the scores then combined for the final PASI. Final PASI calculated as: sum of severity parameters for each region \* area score \* weighing factor \[head (0.1), upper limbs (0.2), trunk (0.3), lower limbs (0.4)\]. Overall scores range from 0 (no PsO) to 72 (the most severe disease).
Percentage of Participants With a Psoriasis Symptoms Scale (PSS) Symptom Score of 0 (Free of Itch, Pain, Stinging, and Burning) in Those With a PSS Symptoms Score ≥1 at Baseline Week 104 PSS is a patient-administered assessment of 4 symptoms (itch, pain, stinging, and burning); 3 signs (redness, scaling, and cracking); and 1 item on the discomfort related to symptoms/signs. The overall severity for each individual symptom/sign from the patient's psoriasis is indicated by selecting the number from a numeric rating scale (NRS) of 0 to 10 that best describes the worst level of each symptom/sign in the past 24 hours, where 0=no symptom/sign and 10=worst imaginable symptom/sign. In addition, a symptoms score ranging from 0 (no symptoms) to 40 (worst imaginable symptoms), and a sign score of 0 (no signs) to 30 (worst imaginable signs) will be reported.
Percentage of Participants Achieving a Dermatology Life Quality Index (DLQI) Total Score of (0,1) With at Least a 5-Point Improvement (Reduction) From Baseline in Participants With a Baseline DLQI Total Score ≥5 Week 104 The DLQI is a patient-reported, 10-question, quality-of-life questionnaire that covers 6 domains including symptoms and feelings, daily activities, leisure, work and school, personal relationships, and treatment. Response categories include "Not at all," "A little," "A lot," and "Very much," with corresponding scores of 0, 1, 2, and 3 respectively. Questions 3-10 also have an additional response category of "Not relevant" which is scored as "0". Totals range from 0 to 30 (less to more impairment). A DLQI total score of 0 to 1 is considered as having no effect on a patient's health-related quality of life (HRQoL), and a 5-point change from baseline is considered as the minimal clinically important difference (MCID) threshold.
Change in Palmoplantar Psoriasis Severity Index (PPASI) Total Score in Participants With Palmoplantar Involvement at Baseline Baseline, Week 104 The PPASI is a composite score derived from the sum scores for erythema, induration, and desquamation multiplied by a score for the extent of palm and sole area involvement, ranging from 0 (no PPASI) to 72 (most severe PPASI). The PPASI was only assessed if participants have palmoplantar psoriasis at baseline.
Change in Psoriasis Scalp Severity Index (PSSI) Total Score in Participants With Scalp Involvement at Baseline Baseline, Week 104 The PSSI is a physician assessment of erythema, induration and desquamation and percent of scalp that is covered with a scores range from 0 (none) to 4 (very severe). The composite score is derived from the sum of scores for erythema, induration, and desquamation multiplied by the score recorded for the extent of the scalp area involved, 1 (\<10%) to 6 (90%-100%) with a total score ranging from 0 (less severity) to 72 (more severity).
Change in Nail Psoriasis Severity Index (NAPSI) Total Score in Participants With Fingernail Involvement at Baseline Baseline, Week 104 The NAPSI scale is used to evaluate the severity of fingernail bed Ps and fingernail matrix PsO by area of involvement. The fingernail is divided into quadrants. Each fingernail is given a score for fingernail bed PsO 0 (none) to 4 (PsO in 4 quadrants of the fingernail) and fingernail matrix PsO 0 (none) to 4 (Ps in 4 quadrants of the matrix), depending on the presence (score of 1) or absence (score of 0) of any of the features of fingernail bed or matrix PsO in each quadrant. The sum of all fingernails equals the total NAPSI score range is from 0 (no effect) to 80 (more severe psoriasis).
Trial Locations
- Locations (228)
Modern Research Associates
🇺🇸Dallas, Texas, United States
Univ of Connecticut
🇺🇸Farmington, Connecticut, United States
Dermatologic Surgery Specialists, PC
🇺🇸Macon, Georgia, United States
Lawrence J Green, M.D, LLC
🇺🇸Rockville, Maryland, United States
Centrum Medyczne Evimed
🇵🇱Warsaw, Mazowieckie, Poland
LASER CLINIC Specjalistyczne Gabinety Lekarskie
🇵🇱Szczecin, Zachodniopomorskie, Poland
Dermed Centrum Medyczne Sp. z o.o.
🇵🇱Lodz, Lodzkie, Poland
Lubelskie Centrum Diagnostyczne
🇵🇱Swidnik, Lubelskie, Poland
Santa Cruz Behavioral PSC
🇵🇷Bayamón, Puerto Rico
Ponce School of Medicine CAIMED Center
🇵🇷Ponce, Puerto Rico
University Hospitals Cleveland Medical Center
🇺🇸Cleveland, Ohio, United States
Texas Dermatology and Laser Specialists
🇺🇸San Antonio, Texas, United States
Dermatologische Gemeinschaftspraxis Mahlow
🇩🇪Mahlow, Brandenburg, Germany
Universitätsklinikum Tübingen
🇩🇪Tübingen, Baden-Württemberg, Germany
National Taiwan University Hospital - Hsinchu branch
🇨🇳Hsinchu, Taiwan
Teikyo University Hospital
🇯🇵Itabashi-ku, Tokyo, Japan
Austin Institute for Clinical Research
🇺🇸Pflugerville, Texas, United States
Woden Dermatology
🇦🇺Phillip, Australian Capital Territory, Australia
Grupo Clinico CATEI Sociedad Civil
🇲🇽Guadalajara, Jalisco, Mexico
Taipei Medical University Shuang Ho Hospital
🇨🇳New Taipei City, Taiwan
Chung Shan Medical University Hospital
🇨🇳Taichung City, Taiwan
Sheba Medical Center
🇮🇱Ramat Gan, Israel
Chonnam National University Hospital
🇰🇷Gwangju, Korea, Korea, Republic of
Tokyo Medical University Hachioji Medical Center
🇯🇵Hachioji, Tokyo, Japan
NZOZ Specjalistyczna Przychodnia Dermatologiczna Specderm
🇵🇱Bialystok, Podlaskie, Poland
University of Alabama at Birmingham
🇺🇸Birmingham, Alabama, United States
Florida Academic Centers Research and Education, LLC
🇺🇸Coral Gables, Florida, United States
First OC Dermatology
🇺🇸Fountain Valley, California, United States
San Luis Dermatology & Laser Clinic
🇺🇸San Luis Obispo, California, United States
Clinical Trials SA Pty Ltd
🇦🇺Adelaide, South Australia, Australia
Nemocnice AGEL Novy Jicin a.s.
🇨🇿Novy Jicin, Moravskoslezsky Kraj, Czechia
Fakultni Nemocnice U svate Anny
🇨🇿Brno, Jihomoravský Kraj, Czechia
Fakultni nemocnice Kralovske Vinohrady
🇨🇿Praha 10, Hl. M. Praha, Czechia
Eastern Canada Cutaneous Research Assoicates Ltd
🇨🇦Halifax, Nova Scotia, Canada
Parra Dermatología
🇦🇷Mendoza, Argentina
Skin Health Institute Inc.
🇦🇺Carlton, Victoria, Australia
Alberta DermaSurgery Centre
🇨🇦Edmonton, Alberta, Canada
Lynderm Research Inc.
🇨🇦Markham, Ontario, Canada
Fremantle Dermatology
🇦🇺Perth, Western Australia, Australia
Dr. Chih-ho Hong Medical Inc.
🇨🇦Surrey, British Columbia, Canada
Klinikum der Johann Wolfgang Goethe-Universität Frankfurt
🇩🇪Frankfurt am Main, Hessen, Germany
CHU de Bordeaux Hop St ANDRE
🇫🇷Bordeaux, Gironde, France
Kožní ambulance Kutná Hora, s.r.o.
🇨🇿Kutna Hora, Středočeský Kraj, Czechia
ISA GmbH
🇩🇪Berlin, Germany
Rosenpark Research GmbH
🇩🇪Darmstadt, Hessen, Germany
Clinical Research Hamburg GmbH
🇩🇪Hamburg, Germany
Dermatologisches Zentrum Osnabrück Nord
🇩🇪Bramsche, Niedersachsen, Germany
Universitätsklinikum Schleswig-Holstein
🇩🇪Lübeck, Schleswig-Holstein, Germany
Debreceni Egyetem Klinikai Kozpont Borgyogyaszati Klinika
🇭🇺Debrecen, Hajdu-Bihar, Hungary
Universitaetsklinikum Hamburg-Eppendorf
🇩🇪Hamburg, Germany
Uno Medical Trials Kft.
🇭🇺Budapest, Hungary
Medmare Bt
🇭🇺Veszprém, Veszprém City, Hungary
Allergo-Derm Bakos Kft
🇭🇺Szolnok, Jasz-Nagykun-Szolnok, Hungary
Ambrozia Kft.
🇭🇺Budapest, Hungary
Rambam Medical Center
🇮🇱Haifa, Israel
Haemek Medical Center- Dermatology
🇮🇱Afula, Israel
Policlinico Gemelli - Università Cattolica del Sacro Cuore
🇮🇹Roma, Lazio, Italy
The University of Tokyo Hospital
🇯🇵Bunkyo-ku, Tokyo, Japan
Policlinico di Tor Vergata
🇮🇹Roma, Italy
Tokai University Hospital- Isehara Campus
🇯🇵Isehara, Kanagawa, Japan
Presidio Ospedaliero Firenze Centro Piero Palagi
🇮🇹Firenze, Italy
Rabin Medical Center
🇮🇱Petach Tikva, Israel
Gunma University Hosptial
🇯🇵Maebashi, Gunma, Japan
Showa University Hospital
🇯🇵Shinagawa, Tokyo, Japan
Tokyo Medical University Hospital
🇯🇵Shinjuku-ku, Tokyo, Japan
Ryukyu University Hospital
🇯🇵Nakagami-gun, Okinawa, Japan
Shiga University of Medical Science Hosptial
🇯🇵Ōtsu, Shiga, Japan
Yamanashi Prefectural Central Hospital
🇯🇵Kofu, Yamanashi, Japan
Osaka City University Hospital
🇯🇵Osaka, Japan
Bucheon St. Mary's Hospital
🇰🇷Bucheon,, Gyeonggi-do, Korea, Republic of
CHA Bundang Medical Center, CHA University
🇰🇷Sungnam-si, Gyeonggi-do, Korea, Republic of
Seoul National University Bundang Hospital
🇰🇷Seongnam-si, Gyeonggi-do, Korea, Republic of
Nippon Life Hospital
🇯🇵Osaka, Japan
Ajou University Hospital
🇰🇷Suwon, Gyeonggi-do, Korea, Republic of
Ilsan Paik Hospital
🇰🇷Goyang-si, Gyeonggi-do, Korea, Republic of
B&B Investigaciones Medicas, SC
🇲🇽Mazatlan, Sinaloa, Mexico
Centro Medico del Angel
🇲🇽Mexicali, Baja California, Mexico
Hospital de Jesus I.A.P.
🇲🇽Mexico City, Distrito Federal, Mexico
Chungang University Hospital
🇰🇷Seoul, Korea, Republic of
Centrum Medyczne AMED
🇵🇱Warsaw, Mazowieckie, Poland
Ai Centrum Medyczne Sp. Z O.O. Sp.K.
🇵🇱Poznan, Wielkopolskie, Poland
RM Pharma Specialists S.A. de C.V.
🇲🇽Distrito Federal, Mexico
Clinica De Enfermedades Cronicas y Procedimientos Especiales
🇲🇽Morelia, Michoacan, Mexico
Köhler & Milstein Research
🇲🇽Mérida, Yucatan, Mexico
Instituto de Investigaciones Aplicadas a la Neurociencia A.C
🇲🇽Durango, Mexico
dermMedica Sp. z o.o.
🇵🇱Wrocław, Dolnośląskie, Poland
DermoDent Centrum Medyczne Aldona Czajkowska Rafał Czajkowski s.c.
🇵🇱Osielsko, Kujawsko-pomorskie, Poland
Diamond Clinic
🇵🇱Krakow, Malopolskie, Poland
Centralny Szpital Kliniczny MSW Klinika Dermatologii
🇵🇱Warszawa, Poland
Centrum Terapii Wspolczesnej J. M. Jasnorzewska Spolka Komandytowo-Akcyjna
🇵🇱Lodz, Łódzkie, Poland
NZOZ ZDROWIE Osteo-Medic
🇵🇱Bialystok, Podlaskie, Poland
Dr. Samuel Sanchez PSC
🇵🇷Caguas, Puerto Rico
Hospital Germans Trias i Pujol
🇪🇸Barcelona, Badalona, Spain
Hospital de Manises
🇪🇸Manises, Valencia, Spain
State scientific centre for dermatovenerology and cosmetolog
🇷🇺Moscow, Russian Federation
Hospital Universitario La Fe de Valencia
🇪🇸Valencia, Spain
Hospital Marina Baixa
🇪🇸Villajoyosa, Alicante, Spain
SPb SBHI Skin-venerologic dispensary #10
🇷🇺St. Petersburg, Russian Federation
Centro de Especialidades Mollabao
🇪🇸Pontevedra, Spain
Hospital De Basurto
🇪🇸Bilbao, Vizcaya, Spain
National Cheng-Kung Uni. Hosp.
🇨🇳Tainan, Taiwan
Chang Gung Memorial Hospital - Linkou
🇨🇳Taoyuan Hsien, Taiwan
National Taiwan University Hospital
🇨🇳Taipei City, Taiwan
Salford Royal NHS Foundation Trust
🇬🇧Salford, Greater Manchester, United Kingdom
Kirk Barber Research
🇨🇦Calgary, Alberta, Canada
Innovaderm Research Inc
🇨🇦Montreal, Quebec, Canada
Nagoya City University Hospital
🇯🇵Nagoya, Aichi, Japan
Toho University School of Medicine, Sakura Hospital
🇯🇵Sakura, Chiba, Japan
Juntendo Urayasu Hospital
🇯🇵Urayasu, Chiba, Japan
Kurume University Hospital
🇯🇵Kurume, Fukuoka, Japan
Asahikawa Medical College Hospital
🇯🇵Asahikawa, Hokkaido, Japan
Takagi Dermatology
🇯🇵Obihiro, Hokkaido, Japan
Tokyo Medical University Ibaraki Medical Center
🇯🇵Inashiki, Ibaraki, Japan
Yokohama City University Hospital
🇯🇵Yokohama, Kanagawa, Japan
Shinshu University Hospital
🇯🇵Matsumoto, Nagano, Japan
Tohoku University Hospital
🇯🇵Sendai-shi, Miyagi, Japan
Kansai Medical University Hospital
🇯🇵Hirakata, Osaka, Japan
Gifu University Hospital
🇯🇵Gifu, Japan
St. Luke's International Hospital
🇯🇵Tokyo, Japan
Shimane University Hospital
🇯🇵Izumo, Shimane, Japan
Takaokashi Shirasaki Dermatology Clinic
🇯🇵Takaoka, Toyama, Japan
Yamaguchi University Hospital
🇯🇵Ube, Yamaguchi, Japan
Kyoto Furitsu Medical University Hospital
🇯🇵Kyoto, Japan
Wakayama Medical University Hospital
🇯🇵Wakayama, Japan
Pusan National University Hospital
🇰🇷Busan, Korea, Korea, Republic of
Gachon University Gil Hospital
🇰🇷Incheon, Korea, Korea, Republic of
Hanyang University Medical Center
🇰🇷Seoul, Korea, Korea, Republic of
Seoul St. Mary's Hospital
🇰🇷Seoul, Korea, Korea, Republic of
Samsung Medical Center
🇰🇷Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of
Ulsan University Hospital
🇰🇷Ulsan, Ulsan-Kwangyǒkshi, Korea, Republic of
Fachklinik Bad Bentheim
🇩🇪Bad Bentheim, Niedersachsen, Germany
Klin. Forschung Berlin-Mitte GmbH
🇩🇪Berlin, Germany
TFS Trial Form Support GmbH
🇩🇪Hamburg, Germany
Hospital Infanta Leonor
🇪🇸Madrid, Spain
Hospital Universitario Virgen Macarena
🇪🇸Sevilla, Spain
Hospital Universitario Ramón y Cajal
🇪🇸Madrid, Spain
GOU VPO 'Smolensk State Medical Academy of Ministry of Health and Social Development of Russian Federation'
🇷🇺Smolensk, Russian Federation
Tver State Medical University
🇷🇺Tver, Russian Federation
Dermatology Clinical Trials
🇺🇸Newport Beach, California, United States
Zenith Research, Inc.
🇺🇸Beverly Hills, California, United States
Keck School of Medicine University of Southern California
🇺🇸Los Angeles, California, United States
Renstar Medical Research
🇺🇸Ocala, Florida, United States
Clinical Science Institute
🇺🇸Santa Monica, California, United States
ForCare Clinical Research
🇺🇸Tampa, Florida, United States
Park Avenue Dermatology
🇺🇸Orange Park, Florida, United States
Arlington Dermatology
🇺🇸Rolling Meadows, Illinois, United States
The Indiana Clinical Trials Center
🇺🇸Plainfield, Indiana, United States
Meridian Clinical Research
🇺🇸Savannah, Georgia, United States
University Dermatology
🇺🇸Darien, Illinois, United States
Forefront Research
🇺🇸Louisville, Kentucky, United States
The South Bend Clinic Center for Research
🇺🇸South Bend, Indiana, United States
DelRicht Research
🇺🇸Baton Rouge, Louisiana, United States
Dermatology and Skin Cancer Specialists
🇺🇸Rockville, Maryland, United States
ORA, Inc
🇺🇸Andover, Massachusetts, United States
Central Dermatology PC
🇺🇸Saint Louis, Missouri, United States
Psoriasis Treatment Center of Central New Jersey
🇺🇸East Windsor, New Jersey, United States
Mount Sinai School of Medicine Dermatology Clinical Trials
🇺🇸New York, New York, United States
Wright State Univ School of Medicine
🇺🇸Fairborn, Ohio, United States
PMG Research of Cary, LLC
🇺🇸Cary, North Carolina, United States
Oregon Health and Science University
🇺🇸Portland, Oregon, United States
Bexley Dermatology Research
🇺🇸Bexley, Ohio, United States
Oregon Dermatology and Research Center
🇺🇸Portland, Oregon, United States
PMG Research of Wilmington
🇺🇸Wilmington, North Carolina, United States
Oregon Medical Research Center
🇺🇸Portland, Oregon, United States
The Pennsylvania Centre for Dermatology, LLC
🇺🇸Exton, Pennsylvania, United States
Clinical Partners, LLC
🇺🇸Johnston, Rhode Island, United States
Virginia Clinical Research, Inc.
🇺🇸Norfolk, Virginia, United States
University of Utah
🇺🇸Murray, Utah, United States
Dermatology Associates
🇺🇸Seattle, Washington, United States
Dermatology
🇦🇷Caba, Buenos Aires, Argentina
MultiCare Good Samaritan Hospital
🇺🇸Tacoma, Washington, United States
Instituto de Neumonología Y Dermatología
🇦🇷Capital Federal, Buenos Aires, Argentina
Psoriahue
🇦🇷Ciudad Autonoma de Buenos Aire, Buenos Aires, Argentina
Clinica Adventista Belgrano
🇦🇷Caba, Ciudad Autónoma De Buenos Aire, Argentina
Centro de Investigaciones Metabólicas (CINME)
🇦🇷Buenos Aires, Argentina
Buenos Aires Skin
🇦🇷Buenos Aires, Ciudad Autónoma De Buenos Aire, Argentina
Clintrial s.r.o.
🇨🇿Praha, Praha 10, Czechia
K. Papp Clinical Research
🇨🇦Waterloo, Ontario, Canada
Etická komise Krajské zdravotní, a.s. - Masarykovy nemocnice v Ústí nad Labem, o.z.
🇨🇿Usti nad Labem, Ustecký Kraj, Czechia
CHU Dupuytren 2
🇫🇷Limoges, Cedex, France
Hopital Saint Eloi
🇫🇷Montpellier, France
CHU de Nice Hopital de L'Archet
🇫🇷Nice cedex 3, France
Cabinet Médical
🇫🇷Martigues, France
CH du Mans - Pavillon Claude Monet
🇫🇷Le Mans Cedex 1, France
CHU Charles Nicolle in Rouen
🇫🇷Rouen cedex, France
Hopital Larrey
🇫🇷Toulouse cedex 9, France
Hautarztpraxis Dr. Leitz
🇩🇪Stuttgart, Baden-Württemberg, Germany
Oroshaza Varosi Onkormanyzat Korhaza
🇭🇺Oroshaza, Bekes, Hungary
Bacs-Kiskun Megyei Korhaz
🇭🇺Kecskemét, Bács-Kiskun, Hungary
Soroka Medical Center
🇮🇱Beer Sheva, Israel
Tel Aviv Sourasky Medical Center
🇮🇱Tel Aviv, Israel
Istituto Clinico Humanitas
🇮🇹Rozzano, Milano, Italy
Mie University Hospital
🇯🇵Tsu, Mie, Japan
Kanto Rosai Hospital
🇯🇵Kawasaki, Kanagawa, Japan
Kume Clinic
🇯🇵Nishi-ku Sakai-shi, Osaka, Japan
Nihon University Itabashi Hospital
🇯🇵Itabashi-ku, Tokyo, Japan
Chungnam National University Hospital
🇰🇷Daejeon, Korea, Korea, Republic of
Kyung Hee University Hospital
🇰🇷Seoul, Korea, Korea, Republic of
Konkuk University Medical Center
🇰🇷Seoul, Korea, Republic of
Severance Hospital, Yonsei University Health System
🇰🇷Seoul, Korea, Republic of
Centrum Badan Klinicznych PI-House sp. z o.o.
🇵🇱Gdansk, Pomorskie, Poland
Centrum Medyczne Angelius Provita
🇵🇱Katowice, Śląskie, Poland
GBUZ Clinical dermatology and venereological dispensary
🇷🇺Krasnodar, Krasnodarskiy Kray, Russian Federation
Hospital Reina Sofia
🇪🇸Cordoba, Spain
Hospital del Mar
🇪🇸Barcelona, Spain
Chang Gung Memorial Hospital - Kaohsiung Branch
🇨🇳Kaohsiung, Taiwan
Elbe Klinikum Buxtehude
🇩🇪Buxtehude, Niedersachsen, Germany
California Dermatology & Clinical Research Institute
🇺🇸Encinitas, California, United States
Advanced Clinical Research LLC
🇺🇸Meridian, Idaho, United States
Dawes Fretzin Clinical Research Group, LLC
🇺🇸Indianapolis, Indiana, United States
University of North Carolina Dermatology and Skin Cancer Cen
🇺🇸Chapel Hill, North Carolina, United States
Halitus Instituto Médico
🇦🇷Ciudad Autonoma de Buenos Aire, Argentina
Hautarztpraxis Dr. Gerlach
🇩🇪Dresden, Sachsen, Germany
Veracity Clinical Research Pty Ltd
🇦🇺Woolloongabba, Queensland, Australia
SKiN Centre for Dermatology
🇨🇦Peterborough, Ontario, Canada
Universitätsklinikum Münster
🇩🇪Münster, Nordrhein-Westfalen, Germany
Charité Campus Virchow-Klinikum
🇩🇪Berlin, Germany
Tokushima University Hospital
🇯🇵Tokushima, Japan
Korea University Guro Hospital
🇰🇷Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of
Nagasaki University Hospital
🇯🇵Nagasaki, Japan
Hospital Universitario La Paz
🇪🇸Madrid, Spain
Office of Dr. Alma M. Cruz
🇵🇷Carolina, Puerto Rico
GCM Medical Group, PSC - Hato Rey Site
🇵🇷San Juan, Puerto Rico
Rothhaar Studien
🇩🇪Berlin, Germany
Guenther Research Inc.
🇨🇦London, Ontario, Canada
Universitätsklinikum Heidelberg
🇩🇪Heidelberg, Baden-Württemberg, Germany
Seibo Hospital
🇯🇵Shinjuku-ku, Tokyo, Japan
NTT Medical Center Tokyo
🇯🇵Shinagawa-KU, Tokyo, Japan