A Long-term Extension Study of Mirikizumab (LY3074828) in Participants With Crohn's Disease

Phase 3

Recruiting

• Conditions: Crohn's Disease
• Interventions: Drug: Mirikizumab

• Registration Number: NCT04232553
• Lead Sponsor: Eli Lilly and Company

Brief Summary

The reason for this study is to determine the long-term efficacy and safety of the study drug mirikizumab in participants with Crohn's disease.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2020-01-15
• Study First Submitted QC: 2020-01-15
• Study First Posted: 2020-01-18
• Study Start: 2020-06-22
• Status Verified: 2024-10
• Last Update Submitted: 2024-10-14
• Last Update Posted: 2024-10-15
• Primary Completion: 2024-11
• Study Completion: 2026-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 778

Inclusion Criteria

• Participants must have completed study I6T-MC-AMAG (NCT02891226) or study I6T-MC-AMAM (NCT03926130)
• If female, participant must meet the contraception requirements

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Exclusion Criteria

• Participants must not have developed a new condition, including cancer in the previous study (I6T-MC-AMAG or I6T-MC-AMAM) that would pose an unacceptable risk in the trial.
• Participants must not have any important infections including, but not limited to, hepatitis B, hepatitis C, HIV/AIDS, and active tuberculosis (TB) during either previous study.

Note: Participants with a history of active TB with documentation of treatment by the Centers for Disease Control (CDC) and/or World Health Organization (WHO) criteria prior to the originator study are not excluded from the study.

• Participants must not have a known hypersensitivity to any component of mirikizumab or have experienced acute systemic hypersensitivity event with previous study drug administration in the originating study that precludes mirikizumab therapy.
• Participation must not be pregnant, lactating, or planning to become pregnant while enrolled in the study or 16 weeks after receiving the last dose of study drug.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Mirikizumab IV and SC	Mirikizumab	Mirikizumab given intravenously (IV) and SC.
Mirikizumab SC	Mirikizumab	Mirikizumab given subcutaneously (SC).

Primary Outcome Measures

Name	Time	Method
Percentage of Participants Achieving Endoscopic Response	Week 52	Endoscopic response based on Simple Endoscopic Score for Crohn's Disease (SES-CD) total score
Percentage of Participants Achieving Clinical Remission	Week 52	Clinical remission based on Crohn's Disease Activity Index (CDAI)

Secondary Outcome Measures

Name	Time	Method
Percentage of Participants Achieving Endoscopic Remission	Week 52	Endoscopic remission based on SES-CD total score
Percentage of Participants Achieving Clinical Response	Week 52	Clinical response by patient-reported outcomes (PRO) based on stool frequency (SF) and abdominal pain (AP)
Change from Baseline in Fecal Calprotectin	Baseline, Week 12	Change from baseline in fecal calprotectin
Change from Baseline on the Inflammatory Bowel Disease Questionnaire (IBDQ)	Baseline to Week 52	Change from baseline on the IBDQ
Change from Baseline in C-Reactive Protein	Baseline, Week 12	Change from baseline in c-reactive protein

Trial Locations

Locations (319)

Digestive Health Specialists; 🇺🇸 Dothan, Alabama, United States

Research Solutions of Arizona; 🇺🇸 Litchfield Park, Arizona, United States

Arizona Arthritis & Rheumatology Associates; 🇺🇸 Phoenix, Arizona, United States

Care Access - Gilroy; 🇺🇸 Gilroy, California, United States

Newport Huntington Medical Group; 🇺🇸 Huntington Beach, California, United States

California Medical Research Associates; 🇺🇸 Northridge, California, United States

Connecticut Clinical Research Institute; 🇺🇸 Bristol, Connecticut, United States

Clinical Research of West Florida, Inc. (Clearwater); 🇺🇸 Clearwater, Florida, United States

IHS Health Research; 🇺🇸 Kissimmee, Florida, United States

Ezy Medical Research; 🇺🇸 Miami, Florida, United States

Care Access - Orlando; 🇺🇸 Orlando, Florida, United States

Gastroenterology Associates of Pensacola, PA; 🇺🇸 Pensacola, Florida, United States

Precision Clinical Research; 🇺🇸 Sunrise, Florida, United States

USF Health; 🇺🇸 Tampa, Florida, United States

Alliance Clinical Research of Tampa; 🇺🇸 Tampa, Florida, United States

Digestive Healthcare of Georgia; 🇺🇸 Atlanta, Georgia, United States

Gastrointestinal Specialists of Georgia; 🇺🇸 Marietta, Georgia, United States

Grand Teton Research Group; 🇺🇸 Idaho Falls, Idaho, United States

Qualmedica Research, LLC; 🇺🇸 Evansville, Indiana, United States

Indiana University Health University Hospital; 🇺🇸 Indianapolis, Indiana, United States

Delta Research Partners; 🇺🇸 Monroe, Louisiana, United States

Capital Digestive Care - Chevy Chase; 🇺🇸 Chevy Chase, Maryland, United States

Woodholme Gastroenterology Associates - Glen Burnie; 🇺🇸 Glen Burnie, Maryland, United States

The Digestive Health Center of Michigan (DHCMI); 🇺🇸 Chesterfield, Michigan, United States

Revive Research Institute, Inc.; 🇺🇸 Farmington Hills, Michigan, United States

MNGI Digestive Health - Plymouth Endoscopy Center & Clinic; 🇺🇸 Plymouth, Minnesota, United States

Washington University Medical School; 🇺🇸 Saint Louis, Missouri, United States

Care Access - Las Vegas; 🇺🇸 Las Vegas, Nevada, United States

Holy Name Medical Center; 🇺🇸 Teaneck, New Jersey, United States

Clinical & Translational Research Center (CTRC); 🇺🇸 Chapel Hill, North Carolina, United States

Carolina Digestive Diseases and Endoscopy Center; 🇺🇸 Greenville, North Carolina, United States

Care Access - Kinston; 🇺🇸 Kinston, North Carolina, United States

University Hospitals Cleveland Medical Center; 🇺🇸 Cleveland, Ohio, United States

Ohio Gastroenterology; 🇺🇸 Columbus, Ohio, United States

Ohio State University; 🇺🇸 Hilliard, Ohio, United States

North Shore Gastroenterology & Endoscopy Centers; 🇺🇸 Westlake, Ohio, United States

The University of Oklahoma Health Sciences Center; 🇺🇸 Oklahoma City, Oklahoma, United States

University Gastroenterology; 🇺🇸 Providence, Rhode Island, United States

Gastroenterology Associates of Orangeburg; 🇺🇸 Orangeburg, South Carolina, United States

Gastroenterology Center Of The Midsouth; 🇺🇸 Cordova, Tennessee, United States

First Surgical Hospital; 🇺🇸 Bellaire, Texas, United States

Baylor College of Medicine Medical Center; 🇺🇸 Houston, Texas, United States

West Texas Digestive Disease; 🇺🇸 Lubbock, Texas, United States

Southern Star Research Institute; 🇺🇸 San Antonio, Texas, United States

Tyler Research Institute; 🇺🇸 Tyler, Texas, United States

Care Access - Ogden; 🇺🇸 Ogden, Utah, United States

Care Access - Salt Lake City; 🇺🇸 Salt Lake City, Utah, United States

University of Virginia Health System; 🇺🇸 Charlottesville, Virginia, United States

Clinical Research Partners, LLC; 🇺🇸 Richmond, Virginia, United States

Tidewater Physicians Multispecialty Group Clinical Research; 🇺🇸 Williamsburg, Virginia, United States

Washington Gastroenterology - Bellevue; 🇺🇸 Bellevue, Washington, United States

Virginia Mason Medical Center; 🇺🇸 Seattle, Washington, United States

Washington Gastroenterology - Tacoma; 🇺🇸 Tacoma, Washington, United States

DOM Centro de Reumatología; 🇦🇷 Ciudad Autónoma de Buenos Aires, Argentina

Concord Repatriation General Hospital; 🇦🇺 Concord, New South Wales, Australia

St Vincent's Hospital; 🇦🇺 Sydney, New South Wales, Australia

Royal Brisbane and Women's Hospital; 🇦🇺 Brisbane, Queensland, Australia

Coastal Digestive Health; 🇦🇺 Maroochydore, Queensland, Australia

Royal Adelaide Hospital; 🇦🇺 Adelaide, South Australia, Australia

The Royal Melbourne Hospital; 🇦🇺 Parkville, Victoria, Australia

Fiona Stanley Hospital; 🇦🇺 Murdoch, Western Australia, Australia

Medizinische Universitaet Innsbruck; 🇦🇹 Innsbruck, Tirol, Austria

Universitaetsklinikum Allgemeines Krankenhaus Wien; 🇦🇹 Vienna, Wien, Austria

Uniklinikum Salzburg; 🇦🇹 Salzburg, Austria

Imelda General Hospital; 🇧🇪 Bonheiden, Antwerpen, Belgium

Université Libre de Bruxelles - Hôpital Erasme; 🇧🇪 Brussels, Bruxelles-Capitale, Région De, Belgium

UZ Gent; 🇧🇪 Gent, Oost-Vlaanderen, Belgium

UZ Leuven; 🇧🇪 Leuven, Vlaams-Brabant, Belgium

CLIAGEN Clínica de Atenção em Gastroenterologia, Especialidades e Nutrição; 🇧🇷 Salvador, Bahia, Brazil

L2IP - Instituto de Pesquisas Clínicas; 🇧🇷 Brasília, Distrito Federal, Brazil

Chronos Pesquisa Clínica; 🇧🇷 Brasília, Distrito Federal, Brazil

Hospital Felicio Rocho; 🇧🇷 Belo Horizonte, Minas Gerais, Brazil

Fundação Universidade de Caxias do Sul (FUCS); 🇧🇷 Caxias do sul, Rio Grande Do Sul, Brazil

Hospital de Clinicas de Porto Alegre; 🇧🇷 Porto Alegre, Rio Grande Do Sul, Brazil

Núcleo de Pesquisa Clínica do Rio Grande do Sul; 🇧🇷 Porto Alegre, Rio Grande Do Sul, Brazil

Hospital Moinhos de Vento; 🇧🇷 Porto Alegre, Rio Grande Do Sul, Brazil

Faculdade de Medicina da UNESP; 🇧🇷 Botucatu, São Paulo, Brazil

Centro de Pesquisa Sao Lucas; 🇧🇷 Campinas, São Paulo, Brazil

Praxis Pesquisa Medica; 🇧🇷 Santo Andre, São Paulo, Brazil

Pesquisare Saude; 🇧🇷 Santo André, São Paulo, Brazil

Centro Multidisciplinar de Estudos Clinicos; 🇧🇷 Sao Bernardo do Campo, São Paulo, Brazil

Hospital Sírio Libanês; 🇧🇷 Sao Paulo, São Paulo, Brazil

CPQuali Pesquisa Clínica; 🇧🇷 São Paulo, Brazil

Instituto de Assistência Médica ao Servidor Público Estadual - IAMSPE/HSPE-FMO Conhecer Centro de Oncolog -T; 🇧🇷 São Paulo, Brazil

Clínica Hepatogastro JK; 🇧🇷 São Paulo, Brazil

Gastroenterology and internal medicine research institute; 🇨🇦 Edmonton, Alberta, Canada

GIRI GI Research Institute - Vancouver; 🇨🇦 Vancouver, British Columbia, Canada

Private Practice - Dr. Bruce Musgrave; 🇨🇦 Kentville, Nova Scotia, Canada

Victoria Hospital; 🇨🇦 London, Ontario, Canada

Private Practice - Dr. Stephane M. Gauthier; 🇨🇦 North Bay, Ontario, Canada

Anhui Provincial Hospital; 🇨🇳 Hefei, Anhui, China

Chongqing General Hospital; 🇨🇳 Chongqing, Chongqing, China

Zhongshan Hospital Affiliated to Xiamen University; 🇨🇳 Xiamen, Fujian, China

The First People's Hospital of Foshan; 🇨🇳 Foshan, Guangdong, China

The Sixth Affiliated Hospital of Sun Yat-sen University; 🇨🇳 Guangzhou, Guangdong, China

The First Affiliated Hospital, Sun Yat-sen University; 🇨🇳 Guangzhou, Guangdong, China

Tongji Hospital Tongji Medical,Science & Technology; 🇨🇳 Wuhan, Hubei, China

Xiangya Hospital Central South University; 🇨🇳 Changsha, Hunan, China

The Second Xiangya Hospital of Central South University; 🇨🇳 Changsha, Hunan, China

The Third Xiangya Hospital of Central South University; 🇨🇳 Changsha, Hunan, China

The First People's Hospital of Changzhou; 🇨🇳 Changzhou, Jiangsu, China

Changzhou No.2 People's Hospital; 🇨🇳 Changzhou, Jiangsu, China

Jiangsu Province Hospital of Chinese Medicine; 🇨🇳 Nanjing, Jiangsu, China

The Second Affiliated Hospital of Soochow University; 🇨🇳 Suzhou, Jiangsu, China

Wuxi People's Hospital; 🇨🇳 Wuxi, Jiangsu, China

Affiliated Hospital of Jiangsu University; 🇨🇳 Zhenjiang, Jiangsu, China

The First Affiliated Hospital of Nanchang University; 🇨🇳 Nanchang, Jiangxi, China

Shengjing Hospital of China Medical University; 🇨🇳 Shenyang, Liaoning, China

Ruijin Hospital Shanghai Jiaotong University School of Medicine; 🇨🇳 Shanghai, Shanghai, China

West China Hospital of Sichuan University; 🇨🇳 ChengDu, Sichuan, China

First Affiliated Hospital of Kunming Medical University; 🇨🇳 Kunming, Yunnan, China

The First Affiliated Hospital, Zhejiang University; 🇨🇳 Hangzhou, Zhejiang, China

Sir Run Run Shaw Hospital; 🇨🇳 Hangzhou, Zhejiang, China

The Second Affiliated hospital of Zhejiang University school of medicine; 🇨🇳 Hangzhou, Zhejiang, China

The Second Affiliated Hospital YuYing Childens Hospital of Wenzhou Medical university; 🇨🇳 Wenzhou, Zhejiang, China

The First Affiliated Hospital Of Fujian Medical University; 🇨🇳 Fuzhou, China

Klinički bolnički centar Zagreb; 🇭🇷 Zagreb, Grad Zagreb, Croatia

Klinički bolnički centar Osijek; 🇭🇷 Osijek, Croatia

Vojenská Nemocnice Brno; 🇨🇿 Brno, Brno-město, Czechia

Fakultni Nemocnice u sv. Anny v Brne; 🇨🇿 Brno, Brno-město, Czechia

Hepato-Gastroenterologie HK; 🇨🇿 Hradec Kralove, Hradec Králové, Czechia

MUDr. Gregar, s.r.o.; 🇨🇿 Olomouc, Olomoucký Kraj, Czechia

MUDr. Radka Koskova, s.r.o.; 🇨🇿 Ostrava, Ostrava Město, Czechia

Synexus Czech; 🇨🇿 Prague, Praha 2, Czechia

Fakultni Thomayerova nemocnice; 🇨🇿 Prague, Praha 4, Czechia

Institut Klinicke a Experimentalni Mediciny; 🇨🇿 Praha, Praha 4, Czechia

AXON Clinical; 🇨🇿 Praha, Praha 5, Czechia

Fakultni nemocnice Motol; 🇨🇿 Praha, Praha 5, Czechia

ISCARE klinické centrum; 🇨🇿 Prague, Praha 9, Czechia

Nemocnice Tomase Bati ve Zline; 🇨🇿 Zlín, Zlínský Kraj, Czechia

Oblastni nemocnice Nachod; 🇨🇿 Nachod, Czechia

PreventaMed; 🇨🇿 Olomouc, Czechia

Masarykova Nemocnice V Usti Nad Labem; 🇨🇿 Usti nad Labem, Ústí Nad Labem, Czechia

Gastroenterologische Praxis Balsiger, Seibold & Partner; 🇨🇭 Bern, Berne, Switzerland

Chu Saint Eloi; 🇫🇷 Montpellier, Languedoc-Roussillon, France

Centre Hospitalier Régional Universitaire de Nancy - Hôpitaux de Brabois; 🇫🇷 Vandœuvre-lès-Nancy, Meurthe-et-Moselle, France

Centre Hospitalier Universitaire de Poitiers; 🇫🇷 Poitiers, Vienne, France

Siloah St. Trudpert Klinikum; 🇩🇪 Pforzheim, Baden-Württemberg, Germany

Universitaetsklinikum Wuerzburg; 🇩🇪 Wuerzburg, Bayern, Germany

Synexus Clinical Research GmbH; 🇩🇪 Frankfurt am Main, Hessen, Germany

Medizinische Hochschule Hannover; 🇩🇪 Hannover, Niedersachsen, Germany

Knappschaftskrankenhaus Bottrop; 🇩🇪 Bottrop, Nordrhein-Westfalen, Germany

Gemeinschaftspraxis Jakobeit; 🇩🇪 Wipperfürth, Nordrhein-Westfalen, Germany

Studiengesellschaft BSF Unternehmergesellschaft; 🇩🇪 Halle (Saale), Sachsen-Anhalt, Germany

Synexus Leipzig Clinical Research Centre; 🇩🇪 Leipzig, Sachsen, Germany

Allgemeine Innere Medizin I; 🇩🇪 Kiel, Schleswig-Holstein, Germany

RED-Institut GmbH; 🇩🇪 Oldenburg, Schleswig-Holstein, Germany

Tumorzentrum Nordthüringen Medizinisches Versorgungszentrum; 🇩🇪 Nordhausen, Thüringen, Germany

Synexus Magyarország Kft; 🇭🇺 Gyula, Békés, Hungary

Bugát Pál Kórház; 🇭🇺 Gyöngyös, Heves, Hungary

Szent Borbala Korhaz; 🇭🇺 Tatabánya, Komárom-Esztergom, Hungary

Jávorszky Ödön Kórház; 🇭🇺 Vác, Pest, Hungary

CLINFAN Szolgáltató Kft; 🇭🇺 Szekszárd, Tolna, Hungary

DRC Gyógyszervizsgáló Központ; 🇭🇺 Balatonfüred, Veszprém, Hungary

Clinexpert Kft.; 🇭🇺 Budapest, Hungary

SYNEXUS Magyarország Kft. Eü.; 🇭🇺 Budapest, Hungary

Pannónia Magánorvosi Centrum; 🇭🇺 Budapest, Hungary

Békés Megyei Központi Kórház Dr. Réthy Pál Tagkórház; 🇭🇺 Békéscsaba, Hungary

All India Institute of Medical Sciences; 🇮🇳 New Delhi, Delhi, India

Sir Ganga Ram Hospital; 🇮🇳 New Delhi, Delhi, India

Gujarat Hospital - Gastro & Vascular Centre; 🇮🇳 Surat, Gujarat, India

Grant Medical Foundation - Ruby Hall Clinic; 🇮🇳 Pune, Maharashtra, India

Dayanand Medical College and Hospital; 🇮🇳 Ludhiana, Punjab, India

SR Kalla Memorial Gastro & General Hospital; 🇮🇳 Jaipur, Rajasthan, India

Apollo Speciality Hospital - Teynampet; 🇮🇳 Chennai, Tamil Nadu, India

Postgraduate Institute of Medical Education & Research; 🇮🇳 Chandigarh, India

Soroka Medical Center; 🇮🇱 Be'er Sheva, HaDarom, Israel

Sheba Medical Center; 🇮🇱 Ramat Gan, HaMerkaz, Israel

Kaplan Medical Center; 🇮🇱 Rehovot, HaMerkaz, Israel

Yitzhak Shamir Medical Center; 🇮🇱 Zerifin, HaMerkaz, Israel

Galilee Medical Center; 🇮🇱 Nahariya, HaTsafon, Israel

Shaare Zedek Medical Center; 🇮🇱 Jerusalem, Yerushalayim, Israel

Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico; 🇮🇹 Milano, Lombardia, Italy

IRCCS Policlinico San Donato; 🇮🇹 Milan, Milano, Italy

Ospedale Di Circolo; 🇮🇹 Rho, Milano, Italy

National Hospital Organization Hirosaki National Hospital; 🇯🇵 Hirosaki, Aomori, Japan

Tsujinaka Hospital Kashiwanoha; 🇯🇵 Kashiwa, Chiba, Japan

Kitakyushu Municipal Medical Center; 🇯🇵 Kitakyusyu-shi, Fukoka, Japan

Fukuoka University Chikushi Hospital; 🇯🇵 Chikushino, Fukuoka, Japan

Kiryu Kosei General Hospital; 🇯🇵 Kiryu, Gunma, Japan

Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital; 🇯🇵 Chuo-ku, Sapporo-shi, Hokkaido, Japan

Tokushukai Sapporo Tokushukai Hospital; 🇯🇵 Sapporo-shi, Hokkaido, Japan

Sapporo Medical University Hospital; 🇯🇵 Sapporo, Hokkaido, Japan

Sapporo Higashi Tokushukai Hospital; 🇯🇵 Sapporo, Hokkaido, Japan

Hyogo College of Medicine; 🇯🇵 Nishinomiya, Hyogo, Japan

Ibaraki Prefectural Central Hospital; 🇯🇵 Kasama, Ibaraki, Japan

Ofuna Central Hospital; 🇯🇵 Kamakura, Kanagawa, Japan

Mie University Hospital; 🇯🇵 Tsu, Mie, Japan

Takagi Clinic - Sendai; 🇯🇵 Sendai, Miyagi, Japan

Matsuaikai Matsuda Hospital; 🇯🇵 Hamamatsu, Shizuoka, Japan

Tokyo Medical And Dental University Medical Hospital; 🇯🇵 Bunkyo, Tokyo, Japan

Kyorin University Hospital; 🇯🇵 Mitaka, Tokyo, Japan

Center Hospital of the National Center for Global Health and Medicine; 🇯🇵 Shinjyuku-ku, Tokyo, Japan

Fukuoka University Hospital; 🇯🇵 Fukuoka, Japan

Kagoshima University Hospital; 🇯🇵 Kagoshima, Japan

Sameshima Hospital; 🇯🇵 Kagoshima, Japan

Kumamoto University; 🇯🇵 Kumamoto, Japan

University Hospital,Kyoto Prefectural University of Medicine; 🇯🇵 Kyoto, Japan

Okayama Saiseikai Outpatient Center Hospital; 🇯🇵 Okayama, Japan

Tokyo Yamate Medical Center; 🇯🇵 Tokyo, Japan

Toyama Prefectural Central Hospital; 🇯🇵 Toyama, Japan

Korea University Ansan Hospital; 🇰🇷 Ansan-si, Gyeonggi-do, Korea, Republic of

Yonsei University-Wonju Severance Christian Hospital; 🇰🇷 Wonju, Kang-won-do, Korea, Republic of

Hanyang University Guri Hospital; 🇰🇷 Guri-si, Kyǒnggi-do, Korea, Republic of

Ajou University Hospital; 🇰🇷 Suwon-si, Kyǒnggi-do, Korea, Republic of

Yeungnam Univeristy Medical Center; 🇰🇷 Gyeongsan-si, Kyǒngsangbuk-do, Korea, Republic of

Dong-A University Hospital; 🇰🇷 Busan, Pusan-Kwangyǒkshi, Korea, Republic of

Inje University Haeundae Paik Hospital; 🇰🇷 Haeundae-gu, Pusan-Kwangyǒkshi, Korea, Republic of

Chung-Ang University Hospital; 🇰🇷 Dongjak-gu, Seoul-teukbyeolsi [Seoul], Korea, Republic of

Kyung Hee University Hospital; 🇰🇷 Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of

Kangbuk Samsung Hospital; 🇰🇷 Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of

Asan Medical Center; 🇰🇷 Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of

The Catholic Univ. of Korea Seoul St. Mary's Hospital; 🇰🇷 Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of

Keimyung University Dongsan Hospital; 🇰🇷 Daegu, Taegu-Kwangyǒkshi, Korea, Republic of

Kyungpook National University Hospital; 🇰🇷 Jung-gu, Taegu-Kwangyǒkshi, Korea, Republic of

Kyungpook National University Chilgok Hospital; 🇰🇷 Deagu, Taegu-Kwan, Korea, Republic of

The Catholic University of Korea, Daejeon St. Mary's Hospital; 🇰🇷 Daejeon, Taejǒn-Kwangyǒkshi, Korea, Republic of

Pauls Stradins Clinical Univeristy Hospital; 🇱🇻 Riga, Rīga, Latvia

Hospital of Lithuanian University of Health Sciences Kaunas; 🇱🇹 Kaunas, Lithuania

Christus Muguerza Hospital Sur; 🇲🇽 Monterrey, Nuevo León, Mexico

Hospital Universitario "Dr. Jose Eleuterio Gonzalez"; 🇲🇽 Monterrey, Nuevo León, Mexico

Centro de Alta Especialidad en Reumatologia e Investigación del Potosi,S.C; 🇲🇽 San Luis Potosi, San Luis Potosí, Mexico

Scientia Investigacion Clinica S.C.; 🇲🇽 Chihuahua, Mexico

Elisabeth-TweeSteden Ziekenhuis; 🇳🇱 Tilburg, Noord-Brabant, Netherlands

Amsterdam UMC, locatie VUmc; 🇳🇱 Amsterdam, Noord-Holland, Netherlands

Melita Medical; 🇵🇱 Wroclaw, Dolnośląskie, Poland

Reumatop; 🇵🇱 Wroclaw, Dolnośląskie, Poland

Synexus - Wroclaw; 🇵🇱 Wroclaw, Dolnośląskie, Poland

Dc-Med; 🇵🇱 Świdnica, Dolnośląskie, Poland

Szpital Uniwersytecki Nr 2 w Bydgoszczy, Klinika Reumatologii i Ukladowych Chorób Tkanki Lacznej; 🇵🇱 Bydgoszcz, Kujawsko-pomorskie, Poland

ZOZ Gastromed; 🇵🇱 Lublin, Lubelskie, Poland

ETG Zamość; 🇵🇱 Zamosc, Lubelskie, Poland

WIP Warsaw IBD Point Profesor Kierkus; 🇵🇱 Warsaw, Mazowieckie, Poland

Centrum Zdrowia MDM; 🇵🇱 Warszawa, Mazowieckie, Poland

Topolowa Medicenter; 🇵🇱 Krakow, Małopolskie, Poland

NZOZ Formed; 🇵🇱 Wadowice, Małopolskie, Poland

Private Practice - Dr. Korczowski Bartosz; 🇵🇱 Rzeszow, Podkarpackie, Poland

Centrum Medyczne MEDYK; 🇵🇱 Rzeszow, Podkarpackie, Poland

Nova Reuma Społka Partnerska; 🇵🇱 Bialystok, Podlaskie, Poland

Synexus Polska Gdansku; 🇵🇱 Gdansk, Pomorskie, Poland

Synexus Polska Sp. z o.o. Oddział w Gdyni; 🇵🇱 Gdynia, Pomorskie, Poland

Endoskopia Sp. z.o.o.; 🇵🇱 Sopot, Pomorskie, Poland

Synexus Polska Sp. z o.o. Oddzial w Czestochowie; 🇵🇱 Czestochowa, Silesian, Poland

NZOZ TwojeZdrowie; 🇵🇱 Elblag, Warmińsko-mazurskie, Poland

Synexus Polska Sp. z o.o. Oddzial w Poznaniu; 🇵🇱 Poznan, Wielkopolskie, Poland

S.C Centrul de Gastroenterologie Dr. Goldis S.R.L; 🇷🇴 Timisoara, Timiș, Romania

Gastromed S.R.L.; 🇷🇴 Constanța, Romania

Poliklinika Agmu "Konsul'tativno-Diagnosticheskiy Tsentr"; 🇷🇺 Barnaul, Altayskiy Kray, Russian Federation

Scientific Centre of Reconstructive and Restorative Surgery; 🇷🇺 Irkutsk, Irkutskaya Oblast', Russian Federation

Karelia Republican Hospital V.A. Baranova; 🇷🇺 Petrozavodsk, Kareliya, Respublika, Russian Federation

Kemerovo Regional Clinical Hospital; 🇷🇺 Kemerovo, Kemerovskaya Oblast', Russian Federation

Olla-Med; 🇷🇺 Moscow, Moskva, Russian Federation

Nizhny Novgorod Regional Hospital N.A. Semashko; 🇷🇺 Nizhny Novgorod, Nizhegorodskaya Oblast', Russian Federation

LLC "Medicine Center SibNovoMed"; 🇷🇺 Novosibirsk, Novosibirskaya Oblast', Russian Federation

Twoja Przychodnia - Szczecinskie Centrum Medyczne; 🇵🇱 Szczecin, Zachodniopomorskie, Poland

SONOMED Centrum Medyczne; 🇵🇱 Szczecin, Zachodniopomorskie, Poland

Synexus Polska - Katowicach; 🇵🇱 Katowice, Śląskie, Poland

Kiepury Clinic; 🇵🇱 Sosnowiec, Śląskie, Poland

Spitalul de Oncologie Monza; 🇷🇴 Bucharest, București, Romania

Delta Health Care; 🇷🇴 Bucharest, București, Romania

S.C. Centrul Medical Medicum SRL; 🇷🇴 Bucuresti, București, Romania

Spitalul Clinic Colentina; 🇷🇴 Bucuresti, București, Romania

Research Institute of Physiology and Fundamental Medicine; 🇷🇺 Novosibirsk, Novosibirskaya Oblast', Russian Federation

Clinic of Omsk State Medical University; 🇷🇺 Omsk, Omskaya Oblast', Russian Federation

Rostov State Medical University; 🇷🇺 Rostov-on-Don, Rostovskaya Oblast', Russian Federation

NonState Healthcare Institution Central Clinical Hospital; 🇷🇺 Samara, Samarskaya Oblast', Russian Federation

LLC Medical Center Reavita Med SPb; 🇷🇺 Saint Petersburg, Sankt-Peterburg, Russian Federation

Balt Med Clinic; 🇷🇺 Saint Petersburg, Sankt-Peterburg, Russian Federation

Saint-Petersburg City Hospital of Saint Elizabeth; 🇷🇺 Saint Petersburg, Sankt-Peterburg, Russian Federation

Scientific research center ECO-security; 🇷🇺 Saint Petersburg, Sankt-Peterburg, Russian Federation

Saint Petersburg State Budgetary Healthcare Institution City Clinical Hospital No.31; 🇷🇺 Saint Petersburg, Sankt-Peterburg, Russian Federation

First Pavlov State Medical University of Saint Petersburg; 🇷🇺 Saint-Petersburg, Sankt-Peterburg, Russian Federation

LLC MA New Hospital; 🇷🇺 Ekaterinburg, Sverdlovskaya Oblast', Russian Federation

Clinical Hospital Center Zvezdara; 🇷🇸 Belgrade, Beograd, Serbia

Clinical Center Bezanijska Kosa; 🇷🇸 Belgrade, Beograd, Serbia

General Hospital "Djordje Joanovic"; 🇷🇸 Zrenjanin, Vojvodina, Serbia

Fakultna nemocnica s poliklinikou F.D.Roosevelta Banska Bystrica; 🇸🇰 Banska Bystrica, Banskobystrický Kraj, Slovakia

Cliniq s.r.o.; 🇸🇰 Bratislava, Bratislavs, Slovakia

Gastromedic; 🇸🇰 Nové Zámky, Nitriansky Kraj, Slovakia

Gastro LM; 🇸🇰 Presov, Prešovský Kraj, Slovakia

Endomed, s.r.o.; 🇸🇰 Vranov N. Toplou, Prešovský Kraj, Slovakia

Cantonal Hospital St.Gallen; 🇨🇭 st.Gallen, Sankt Gallen, Switzerland

Inselspital Bern; 🇨🇭 Berne, Switzerland

Dokuz Eylül Üniversitesi; 🇹🇷 Izmir, Balçova, Turkey

Eskisehir Osmangazi University; 🇹🇷 Eskisehir, Eskişehir, Turkey

Istanbul Universitesi Cerrahpasa; 🇹🇷 Istanbul-Fatih, İstanbul, Turkey

Kocaeli University Medical Faculty Hospital; 🇹🇷 Izmit, Kocaeli, Turkey

Ankara City Hospital; 🇹🇷 Ankara, Turkey

Hacettepe Universite Hastaneleri; 🇹🇷 Ankara, Turkey

Gazi University Health Research and Application Center Gazi Hospital; 🇹🇷 Ankara, Turkey

Antalya Egitim ve Arastırma Hastanesi; 🇹🇷 Antalya, Turkey

Uludag Universitesi; 🇹🇷 Bursa, Turkey

Trakya University; 🇹🇷 Edirne, Turkey

Mustafa Kemal Universitesi; 🇹🇷 Hatay, Turkey

Medicana Kadiköy Hastanesi; 🇹🇷 Istanbul, Turkey

Acbadem Kozyatagi Hospital; 🇹🇷 Istanbul, Turkey

Mersin University; 🇹🇷 Mersin, Turkey

Medical Center Family Medicine Clinic; 🇺🇦 Dnipro, Dnipropetrovska Oblast, Ukraine

Communal non-profit enterprise "Regional clinical hospital of Ivano-Frankivsk Regional Council"; 🇺🇦 Ivano-Frankivsk, Ivano-Frankivska Oblast, Ukraine

City Clinical Hospital No. 2; 🇺🇦 Kharkiv, Kharkivska Oblast, Ukraine

Medbud Clinic; 🇺🇦 Kyiv, Kyivska Oblast, Ukraine

Lviv Railway Clinical Hospital; 🇺🇦 Lviv, Lvivska Oblast, Ukraine

Municipal non-profit enterprise'Odesa Regional Clinical Hospital'of Odesa Regional Council; 🇺🇦 Odesa, Odeska Oblast, Ukraine

Medical Clinical Investigational Center of Medical Center Health Clinic; 🇺🇦 Vinnytsia, Vinnytska Oblast, Ukraine

City Clinical Hospital #1, Vinnitsya National Medical University; 🇺🇦 Vinnytsya, Vinnytska Oblast, Ukraine

Municipal Nonprofit Enterprise "Vinnytsia Regional Clinical Hospital n.a. M. I. Pyrohov of Vinnytsia Regio -T; 🇺🇦 Vinnytsya, Vinnytska Oblast, Ukraine

VNMU; 🇺🇦 Vinnytsya, Vinnytska Oblast, Ukraine

Transcarpathian Regional Hospital im.Andriya Novak; 🇺🇦 Uzhgorod, Zakarpatska Oblast, Ukraine

Communal Non-profit Enterprise "City Hospital #6" of Zaporizhzhia City Council; 🇺🇦 Zaporizhia, Zaporizka Oblast, Ukraine

Diacenter; 🇺🇦 Zaporizhzhia, Zaporizka Oblast, Ukraine

Chernivtsi Regional Clinical Hospital; 🇺🇦 Chernivtsi, Ukraine

Medical Center Ok!Clinic+; 🇺🇦 Kyiv, Ukraine

Kyiv Railway Clinical Hospital No.2 of Branch Health Center of the Public Joint Stock Company Ukrainian Ra -T; 🇺🇦 Kyiv, Ukraine

Medical Center of Limited Liability Company "Medical Center "Consilium Medical"; 🇺🇦 Kyiv, Ukraine

Municipal non-profit enterprise of Kyiv Regional Council "Kyiv Regional Center for Rehabilitation Medicine"; 🇺🇦 Kyiv, Ukraine

Municipal Nonprofit Enterprise of Kyiv Region Council "Kyiv Regional Clinical Hospital"; 🇺🇦 Kyiv, Ukraine

Addenbrooke's Hospital; 🇬🇧 Cambridge, Cambridgeshire, United Kingdom

Whipps Cross University Hospital; 🇬🇧 London, England, United Kingdom

Synexus Wales Clinical Research Centre; 🇬🇧 Cardiff, United Kingdom