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Alnylam Pharmaceuticals

πŸ‡ΊπŸ‡ΈUnited States
Ownership
-
Established
2002-01-01
Employees
-
Market Cap
$35.9B
Website
http://www.alnylam.com/

Clinical Trials

77

Active:4
Completed:42

Trial Phases

4 Phases

Phase 1:29
Phase 2:16
Phase 3:14
+1 more phases

Drug Approvals

0

Drug Approvals

No drug approvals found

This company may not have drug approvals in our database

Clinical Trials

Distribution across different clinical trial phases (63 trials with phase data)β€’ Click on a phase to view related trials

Phase 1
29 (46.0%)
Phase 2
16 (25.4%)
Phase 3
14 (22.2%)
Not Applicable
4 (6.3%)

TRITON-PN: A Study to Evaluate the Efficacy and Safety of Nucresiran in Patients With Hereditary Transthyretin Amyloidosis With Polyneuropathy

Not Applicable
Not yet recruiting
Conditions
Hereditary Transthyretin-Mediated Amyloidosis With Polyneuropathy
hATTR-PN
Interventions
First Posted Date
2025-10-31
Last Posted Date
2025-10-31
Lead Sponsor
Alnylam Pharmaceuticals
Target Recruit Count
125
Registration Number
NCT07223203

A Study to Evaluate ALN-5288 in Patients With Alzheimer's Disease

Not Applicable
Recruiting
Conditions
Alzheimer's Disease
Interventions
Drug: ALN-5288
Drug: Placebo
First Posted Date
2025-10-09
Last Posted Date
2025-11-13
Lead Sponsor
Alnylam Pharmaceuticals
Target Recruit Count
50
Registration Number
NCT07214727
Locations
πŸ‡¬πŸ‡§

Clinical Trial Site, Southampton, United Kingdom

Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease

Not Applicable
Recruiting
Conditions
High Risk Cardiovascular Disease
Hypertension
High Cardiovascular Risk
Interventions
Drug: Placebo
First Posted Date
2025-09-18
Last Posted Date
2025-11-04
Lead Sponsor
Alnylam Pharmaceuticals
Target Recruit Count
11000
Registration Number
NCT07181109
Locations
πŸ‡ΊπŸ‡Έ

Clinical Trial Site, Bountiful, Utah, United States

TRITON-CM: A Study to Evaluate Nucresiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy

Not Applicable
Recruiting
Conditions
Transthyretin Amyloidosis With Cardiomyopathy
Interventions
Drug: Sterile Normal Saline (0.9% NaCl)
First Posted Date
2025-07-08
Last Posted Date
2025-11-13
Lead Sponsor
Alnylam Pharmaceuticals
Target Recruit Count
1250
Registration Number
NCT07052903
Locations
πŸ‡ͺπŸ‡Έ

Clinical Trial Site-1, Valencia, Spain

πŸ‡ͺπŸ‡Έ

Clinical Trial Site-2, Valencia, Spain

πŸ‡¬πŸ‡§

Clinical Trial Site, Manchester, United Kingdom

A Study to Evaluate ALN-4324 in Overweight to Obese Healthy Volunteers and in Overweight to Obese Patients With T2DM

Phase 1
Recruiting
Conditions
Obese or Overweight Healthy Volunteers
Type 2 Diabetes Mellitus (T2DM)
Interventions
Drug: ALN-4324
Drug: Placebo
First Posted Date
2025-02-25
Last Posted Date
2025-11-12
Lead Sponsor
Alnylam Pharmaceuticals
Target Recruit Count
144
Registration Number
NCT06845202
Locations
πŸ‡΅πŸ‡±

Clinical Trial Site, Warsaw, Poland

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News

Vir Biotechnology to Present 48-Week SOLSTICE Trial Results for Hepatitis Delta Combination Therapy at AASLD 2025

Vir Biotechnology will present Week 48 endpoint results from the Phase 2 SOLSTICE trial evaluating tobevibart alone or in combination with elebsiran for chronic hepatitis delta at AASLD 2025.

Ultragenyx Appoints Eric Olson as Chief Business Officer to Lead Rare Disease Pipeline Expansion

Ultragenyx Pharmaceutical appointed Eric Olson as Chief Business Officer and Executive Vice President effective September 22, 2025, following Thomas Kassberg's planned retirement after 14 years with the company.

Huntington's Disease Pipeline Shows Strong Growth with Over 20 Companies Developing Novel Therapies

Over 20 pharmaceutical and biotech companies are actively developing more than 20 therapeutic candidates for Huntington's disease at various clinical and preclinical stages.

Moderna Settles Patent Dispute with Alnylam Over COVID-19 Vaccine Technology

Moderna has settled patent infringement lawsuits filed by Alnylam Pharmaceuticals over alleged misuse of lipid nanoparticle technology in COVID-19 vaccines.

Alnylam Pharmaceuticals Joins Alliance for Genomic Discovery to Accelerate RNAi Drug Development

Alnylam Pharmaceuticals has joined the Alliance for Genomic Discovery as the ninth member, gaining access to a comprehensive clinical genomic database containing 250,000 whole-genomes to accelerate RNA interference therapeutic development.

Biotech Veterans Launch Corsera Health with Annual RNAi Drug to Prevent Cardiovascular Disease

Biotech leaders John Maraganore and Clive Meanwell have launched Corsera Health with the ambitious goal of creating a world without cardiovascular disease.

Alnylam's Zilebesiran Advances to Phase III ZENITH Trial for Hypertension Treatment

Zilebesiran, developed by Alnylam Pharmaceuticals and Roche, targets angiotensinogen in the renin-angiotensin-aldosterone system and offers biannual dosing for hypertension management.

Delaware Court Rules Pfizer COVID-19 Vaccine Does Not Infringe Alnylam's Nanoparticle Patents

The U.S. District Court for the District of Delaware entered a final judgment on July 30, 2025, ruling that Pfizer's COVID-19 vaccine did not infringe any of Alnylam's patents covering nanoparticle technology.

FDA Approves Leqvio as First-Line Monotherapy for Cholesterol Management

The FDA has approved an updated label for Novartis' Leqvio (inclisiran) allowing its use as monotherapy alongside diet and exercise to reduce LDL cholesterol in adults with hypercholesterolemia.

Federal Circuit Upholds Moderna Victory in COVID-19 Vaccine Patent Dispute with Alnylam

The U.S. Court of Appeals for the Federal Circuit affirmed a district court ruling in favor of Moderna, rejecting Alnylam Pharmaceuticals' patent infringement claims over mRNA-based COVID-19 vaccine technology.

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