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Alnylam Pharmaceuticals

🇺🇸United States
Ownership
-
Established
2002-01-01
Employees
-
Market Cap
$35.9B
Website
http://www.alnylam.com/

Clinical Trials

75

Active:6
Completed:41

Trial Phases

4 Phases

Phase 1:29
Phase 2:16
Phase 3:14
+1 more phases

Drug Approvals

0

Drug Approvals

No drug approvals found

This company may not have drug approvals in our database

Clinical Trials

Distribution across different clinical trial phases (61 trials with phase data)• Click on a phase to view related trials

Phase 1
29 (47.5%)
Phase 2
16 (26.2%)
Phase 3
14 (23.0%)
Not Applicable
2 (3.3%)

Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease

Not Applicable
Recruiting
Conditions
High Risk Cardiovascular Disease
Hypertension
High Cardiovascular Risk
Interventions
Drug: Placebo
First Posted Date
2025-09-18
Last Posted Date
2025-09-18
Lead Sponsor
Alnylam Pharmaceuticals
Target Recruit Count
11000
Registration Number
NCT07181109
Locations
🇺🇸

Clinical Trial Site, Mesquite, Texas, United States

TRITON-CM: A Study to Evaluate Nucresiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy

Not Applicable
Recruiting
Conditions
Transthyretin Amyloidosis With Cardiomyopathy
Interventions
Drug: Sterile Normal Saline (0.9% NaCl)
First Posted Date
2025-07-08
Last Posted Date
2025-09-18
Lead Sponsor
Alnylam Pharmaceuticals
Target Recruit Count
1250
Registration Number
NCT07052903
Locations
🇺🇸

Clinical Trial Site, Philadelphia, Pennsylvania, United States

A Phase 1 Study to Evaluate ALN-4324 in Overweight to Obese Healthy Volunteers

Phase 1
Recruiting
Conditions
Obese or Overweight Healthy Volunteers
Interventions
Drug: ALN-4324
Drug: Placebo
First Posted Date
2025-02-25
Last Posted Date
2025-07-16
Lead Sponsor
Alnylam Pharmaceuticals
Target Recruit Count
84
Registration Number
NCT06845202
Locations
🇨🇦

Clinical Trial Site, Laval, Quebec, Canada

A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy

Phase 3
Conditions
Transthyretin Amyloidosis (ATTR) With Cardiomyopathy
Interventions
First Posted Date
2024-11-08
Last Posted Date
2025-09-19
Lead Sponsor
Alnylam Pharmaceuticals
Target Recruit Count
700
Registration Number
NCT06679946
Locations
🇬🇧

Clinical Trial Site, Manchester, United Kingdom

A Study to Evaluate ALN-AGT01 RVR in Adult Healthy Volunteers

Phase 1
Completed
Conditions
Healthy Volunteers
Interventions
Drug: Placebo
Drug: ALN-AGT01 RVR
First Posted Date
2024-11-05
Last Posted Date
2025-09-19
Lead Sponsor
Alnylam Pharmaceuticals
Target Recruit Count
42
Registration Number
NCT06675565
Locations
🇨🇦

Clinical Trial Site, Montreal, Canada

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News

Moderna Settles Patent Dispute with Alnylam Over COVID-19 Vaccine Technology

Moderna has settled patent infringement lawsuits filed by Alnylam Pharmaceuticals over alleged misuse of lipid nanoparticle technology in COVID-19 vaccines.

Alnylam Pharmaceuticals Joins Alliance for Genomic Discovery to Accelerate RNAi Drug Development

Alnylam Pharmaceuticals has joined the Alliance for Genomic Discovery as the ninth member, gaining access to a comprehensive clinical genomic database containing 250,000 whole-genomes to accelerate RNA interference therapeutic development.

Biotech Veterans Launch Corsera Health with Annual RNAi Drug to Prevent Cardiovascular Disease

Biotech leaders John Maraganore and Clive Meanwell have launched Corsera Health with the ambitious goal of creating a world without cardiovascular disease.

Alnylam's Zilebesiran Advances to Phase III ZENITH Trial for Hypertension Treatment

Zilebesiran, developed by Alnylam Pharmaceuticals and Roche, targets angiotensinogen in the renin-angiotensin-aldosterone system and offers biannual dosing for hypertension management.

Delaware Court Rules Pfizer COVID-19 Vaccine Does Not Infringe Alnylam's Nanoparticle Patents

The U.S. District Court for the District of Delaware entered a final judgment on July 30, 2025, ruling that Pfizer's COVID-19 vaccine did not infringe any of Alnylam's patents covering nanoparticle technology.

FDA Approves Leqvio as First-Line Monotherapy for Cholesterol Management

The FDA has approved an updated label for Novartis' Leqvio (inclisiran) allowing its use as monotherapy alongside diet and exercise to reduce LDL cholesterol in adults with hypercholesterolemia.

Federal Circuit Upholds Moderna Victory in COVID-19 Vaccine Patent Dispute with Alnylam

The U.S. Court of Appeals for the Federal Circuit affirmed a district court ruling in favor of Moderna, rejecting Alnylam Pharmaceuticals' patent infringement claims over mRNA-based COVID-19 vaccine technology.

Huntington's Disease Pipeline Shows Robust Growth with 20+ Companies Developing Novel Therapies

DelveInsight's 2025 pipeline analysis reveals over 20 active companies developing more than 20 pipeline drugs for Huntington's disease, including gene-targeting and disease-modifying therapies.

New Cryogenic Mass Spectrometry Method Reveals Lipid Nanoparticle Structure, Advancing RNA Therapeutics

Scientists at the University of Nottingham have developed a cryogenic mass spectrometry approach that reveals the precise structure and molecular orientation within lipid nanoparticles used in RNA therapeutics.

New Report Reveals Trends in Pharmaceutical and Biotechnology Royalty Rates from 2010-2025

• Comprehensive analysis of 700+ pharmaceutical and biotechnology partnering deals with disclosed royalty rates from 2010-2025 has been published by ResearchAndMarkets.com. • The report provides unprecedented access to actual contract documents submitted to the SEC, offering detailed insights into royalty rate structures and their integration with other financial terms. • Key industry players including AbbVie, Pfizer, Novartis, and Bristol-Myers Squibb are featured among the 50+ companies actively disclosing royalty rates in their partnership agreements.

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