Which is the best endoscopic treatment for achalasia in children?

Not Applicable

• Conditions: Achalasia; Digestive System; Achalasia of cardia

• Registration Number: ISRCTN74448884
• Lead Sponsor: Amsterdam University Medical Centers

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2022-02-18
• Last Update Posted: 1 March 2022
• Study Completion: 2026-12-31

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

1. Eckardt score >3
2. Presence of a HRM pattern consistent with achalasia type I or II according to the Chicago classification (CC) V3.0 criteria
3. Age 7 years up to 17 years inclusive

Exclusion Criteria

1. Achalasia type III (this extremely rare subtype in children that is accompanied by esophageal spasm and associated complaints has a worse prognosis compared to type I and II. Literature and expert-opinion based recommendations suggest to treat type III with POEM. Randomizing these patients to EBD with a high a priori risk of relapses is therefore considered unethical)
2. Previous surgical or endoscopical achalasia treatment
3. Previous surgery of the upper gastrointestinal tract
4. Known coagulopathy
5. Known Liver cirrhosis and/or esophageal varices
6. Known LA grade =B esophagitis
7. Known Barrett’s esophagus
8. Known pregnancy at time of treatment
9. Stricture of the esophagus
10. Known presence of malignant or premalignant esophageal lesions
11. Hiatal hernia >1 cm based on HRM measurement
12. Extensive, tortuous dilatation (>7 cm luminal diameter, S shape) of the esophagus
13. Barium esophagram suggestive of other pathologies

Study & Design

• Study Type: Interventional
• Study Design: Not specified